Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation
Matrix metalloproteinases (MMPs) have been implicated in a variety of normal and pathological conditions that involve matrix degradation and remodelling. We investigated the role of MMPs in acute graft-versus-host disease (aGVHD) in 29 patients who had undergone allogeneic haematopoietic stem cell t...
Gespeichert in:
| Veröffentlicht in: | International journal of hematology 2009-09, Vol.90 (2), p.248-252 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 252 |
|---|---|
| container_issue | 2 |
| container_start_page | 248 |
| container_title | International journal of hematology |
| container_volume | 90 |
| creator | Tagami, Kozo Yujiri, Toshiaki Takahashi, Toru Kizuki, Nobuaki Tanaka, Yoshinori Mitani, Noriyuki Nakamura, Yukinori Ariyoshi, Koichi Ando, Toshihiko Gondo, Toshikazu Tanizawa, Yukio |
| description | Matrix metalloproteinases (MMPs) have been implicated in a variety of normal and pathological conditions that involve matrix degradation and remodelling. We investigated the role of MMPs in acute graft-versus-host disease (aGVHD) in 29 patients who had undergone allogeneic haematopoietic stem cell transplantation. The present study showed that the serum levels of MMP-9, but not those of MMP-2, significantly correlated with the occurrence and severity of aGVHD. Moreover, immunohistochemical analysis of the cutaneous lesions of patients with aGVHD revealed an increased number of inflammatory cells positive for MMP-9. These results suggest that MMP-9 might play an important role in the pathogenesis of aGVHD. |
| doi_str_mv | 10.1007/s12185-009-0358-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_745903272</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1891669841</sourcerecordid><originalsourceid>FETCH-LOGICAL-c614t-abac64849bad61d3bfe7ce0817acc66c7cb61ead3764a0debe00dc41fbcb8ffe3</originalsourceid><addsrcrecordid>eNqNkl1rFTEQhoNY7PHoD_BGgqBeRWf2I9m9lOJHodAbvV6y2dnTlP04ZrKl_gz_sdmegwXB0quQ5Jl33kleIV4hfEAA85Exw6pUALWCvKyUfiI2WOlS5cYUT8UG6qxUpUE4Fc-ZrwHQQGGeiVOsy6ICXW_E7_PJBbJMnWQKyygHuqGB5dzL0cbgb-VI0Q7DvA9zJD8lUtXST9K6JZLcBdtHdUOBF1ZXM0fZeV7lZDqnINfKHU3knbyylBTn_ewppi1HGqWjYZAx2In3g52ijX6eXoiT3g5ML4_rVvz48vn72Td1cfn1_OzThXIai6hsa50uqqJubaexy9uejCOo0FjntHbGtRrJdrnRhYWOWgLoXIF969qq7ynfivcH3TTZz4U4NqPn1ZCdaF64MUVZQ56Z7DGkyWrA_BFkoU2OGhL57kFSGw2ImUngm3_A63kJU3qZJkOTpsvv1PAAuTAzB-qbffCjDb8ahGaNSnOISpOi0qxRaXSqeX0UXtqRuvuKYzYS8PYIWHZ26NM3Oc9_uQzrClcLW5EdOE5X047CvcP_d_8DgkbaMQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>217376360</pqid></control><display><type>article</type><title>Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Tagami, Kozo ; Yujiri, Toshiaki ; Takahashi, Toru ; Kizuki, Nobuaki ; Tanaka, Yoshinori ; Mitani, Noriyuki ; Nakamura, Yukinori ; Ariyoshi, Koichi ; Ando, Toshihiko ; Gondo, Toshikazu ; Tanizawa, Yukio</creator><creatorcontrib>Tagami, Kozo ; Yujiri, Toshiaki ; Takahashi, Toru ; Kizuki, Nobuaki ; Tanaka, Yoshinori ; Mitani, Noriyuki ; Nakamura, Yukinori ; Ariyoshi, Koichi ; Ando, Toshihiko ; Gondo, Toshikazu ; Tanizawa, Yukio</creatorcontrib><description>Matrix metalloproteinases (MMPs) have been implicated in a variety of normal and pathological conditions that involve matrix degradation and remodelling. We investigated the role of MMPs in acute graft-versus-host disease (aGVHD) in 29 patients who had undergone allogeneic haematopoietic stem cell transplantation. The present study showed that the serum levels of MMP-9, but not those of MMP-2, significantly correlated with the occurrence and severity of aGVHD. Moreover, immunohistochemical analysis of the cutaneous lesions of patients with aGVHD revealed an increased number of inflammatory cells positive for MMP-9. These results suggest that MMP-9 might play an important role in the pathogenesis of aGVHD.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-009-0358-6</identifier><identifier>PMID: 19548069</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Acute Disease ; Adolescent ; Adult ; Biological and medical sciences ; Biopsy ; Female ; Graft vs Host Disease - blood ; Graft vs Host Disease - etiology ; Graft vs Host Disease - pathology ; Hematologic and hematopoietic diseases ; Hematology ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Leukemia - therapy ; Male ; Matrix Metalloproteinase 2 - blood ; Matrix Metalloproteinase 9 - blood ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Article ; Skin - pathology ; Transplantation, Homologous ; Young Adult</subject><ispartof>International journal of hematology, 2009-09, Vol.90 (2), p.248-252</ispartof><rights>The Japanese Society of Hematology 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c614t-abac64849bad61d3bfe7ce0817acc66c7cb61ead3764a0debe00dc41fbcb8ffe3</citedby><cites>FETCH-LOGICAL-c614t-abac64849bad61d3bfe7ce0817acc66c7cb61ead3764a0debe00dc41fbcb8ffe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12185-009-0358-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12185-009-0358-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21981217$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19548069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tagami, Kozo</creatorcontrib><creatorcontrib>Yujiri, Toshiaki</creatorcontrib><creatorcontrib>Takahashi, Toru</creatorcontrib><creatorcontrib>Kizuki, Nobuaki</creatorcontrib><creatorcontrib>Tanaka, Yoshinori</creatorcontrib><creatorcontrib>Mitani, Noriyuki</creatorcontrib><creatorcontrib>Nakamura, Yukinori</creatorcontrib><creatorcontrib>Ariyoshi, Koichi</creatorcontrib><creatorcontrib>Ando, Toshihiko</creatorcontrib><creatorcontrib>Gondo, Toshikazu</creatorcontrib><creatorcontrib>Tanizawa, Yukio</creatorcontrib><title>Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>Matrix metalloproteinases (MMPs) have been implicated in a variety of normal and pathological conditions that involve matrix degradation and remodelling. We investigated the role of MMPs in acute graft-versus-host disease (aGVHD) in 29 patients who had undergone allogeneic haematopoietic stem cell transplantation. The present study showed that the serum levels of MMP-9, but not those of MMP-2, significantly correlated with the occurrence and severity of aGVHD. Moreover, immunohistochemical analysis of the cutaneous lesions of patients with aGVHD revealed an increased number of inflammatory cells positive for MMP-9. These results suggest that MMP-9 might play an important role in the pathogenesis of aGVHD.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Female</subject><subject>Graft vs Host Disease - blood</subject><subject>Graft vs Host Disease - etiology</subject><subject>Graft vs Host Disease - pathology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Humans</subject><subject>Leukemia - therapy</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - blood</subject><subject>Matrix Metalloproteinase 9 - blood</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Skin - pathology</subject><subject>Transplantation, Homologous</subject><subject>Young Adult</subject><issn>0925-5710</issn><issn>1865-3774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkl1rFTEQhoNY7PHoD_BGgqBeRWf2I9m9lOJHodAbvV6y2dnTlP04ZrKl_gz_sdmegwXB0quQ5Jl33kleIV4hfEAA85Exw6pUALWCvKyUfiI2WOlS5cYUT8UG6qxUpUE4Fc-ZrwHQQGGeiVOsy6ICXW_E7_PJBbJMnWQKyygHuqGB5dzL0cbgb-VI0Q7DvA9zJD8lUtXST9K6JZLcBdtHdUOBF1ZXM0fZeV7lZDqnINfKHU3knbyylBTn_ewppi1HGqWjYZAx2In3g52ijX6eXoiT3g5ML4_rVvz48vn72Td1cfn1_OzThXIai6hsa50uqqJubaexy9uejCOo0FjntHbGtRrJdrnRhYWOWgLoXIF969qq7ynfivcH3TTZz4U4NqPn1ZCdaF64MUVZQ56Z7DGkyWrA_BFkoU2OGhL57kFSGw2ImUngm3_A63kJU3qZJkOTpsvv1PAAuTAzB-qbffCjDb8ahGaNSnOISpOi0qxRaXSqeX0UXtqRuvuKYzYS8PYIWHZ26NM3Oc9_uQzrClcLW5EdOE5X047CvcP_d_8DgkbaMQ</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Tagami, Kozo</creator><creator>Yujiri, Toshiaki</creator><creator>Takahashi, Toru</creator><creator>Kizuki, Nobuaki</creator><creator>Tanaka, Yoshinori</creator><creator>Mitani, Noriyuki</creator><creator>Nakamura, Yukinori</creator><creator>Ariyoshi, Koichi</creator><creator>Ando, Toshihiko</creator><creator>Gondo, Toshikazu</creator><creator>Tanizawa, Yukio</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation</title><author>Tagami, Kozo ; Yujiri, Toshiaki ; Takahashi, Toru ; Kizuki, Nobuaki ; Tanaka, Yoshinori ; Mitani, Noriyuki ; Nakamura, Yukinori ; Ariyoshi, Koichi ; Ando, Toshihiko ; Gondo, Toshikazu ; Tanizawa, Yukio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c614t-abac64849bad61d3bfe7ce0817acc66c7cb61ead3764a0debe00dc41fbcb8ffe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Female</topic><topic>Graft vs Host Disease - blood</topic><topic>Graft vs Host Disease - etiology</topic><topic>Graft vs Host Disease - pathology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Humans</topic><topic>Leukemia - therapy</topic><topic>Male</topic><topic>Matrix Metalloproteinase 2 - blood</topic><topic>Matrix Metalloproteinase 9 - blood</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Skin - pathology</topic><topic>Transplantation, Homologous</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tagami, Kozo</creatorcontrib><creatorcontrib>Yujiri, Toshiaki</creatorcontrib><creatorcontrib>Takahashi, Toru</creatorcontrib><creatorcontrib>Kizuki, Nobuaki</creatorcontrib><creatorcontrib>Tanaka, Yoshinori</creatorcontrib><creatorcontrib>Mitani, Noriyuki</creatorcontrib><creatorcontrib>Nakamura, Yukinori</creatorcontrib><creatorcontrib>Ariyoshi, Koichi</creatorcontrib><creatorcontrib>Ando, Toshihiko</creatorcontrib><creatorcontrib>Gondo, Toshikazu</creatorcontrib><creatorcontrib>Tanizawa, Yukio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tagami, Kozo</au><au>Yujiri, Toshiaki</au><au>Takahashi, Toru</au><au>Kizuki, Nobuaki</au><au>Tanaka, Yoshinori</au><au>Mitani, Noriyuki</au><au>Nakamura, Yukinori</au><au>Ariyoshi, Koichi</au><au>Ando, Toshihiko</au><au>Gondo, Toshikazu</au><au>Tanizawa, Yukio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>90</volume><issue>2</issue><spage>248</spage><epage>252</epage><pages>248-252</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>Matrix metalloproteinases (MMPs) have been implicated in a variety of normal and pathological conditions that involve matrix degradation and remodelling. We investigated the role of MMPs in acute graft-versus-host disease (aGVHD) in 29 patients who had undergone allogeneic haematopoietic stem cell transplantation. The present study showed that the serum levels of MMP-9, but not those of MMP-2, significantly correlated with the occurrence and severity of aGVHD. Moreover, immunohistochemical analysis of the cutaneous lesions of patients with aGVHD revealed an increased number of inflammatory cells positive for MMP-9. These results suggest that MMP-9 might play an important role in the pathogenesis of aGVHD.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>19548069</pmid><doi>10.1007/s12185-009-0358-6</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0925-5710 |
| ispartof | International journal of hematology, 2009-09, Vol.90 (2), p.248-252 |
| issn | 0925-5710 1865-3774 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_745903272 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acute Disease Adolescent Adult Biological and medical sciences Biopsy Female Graft vs Host Disease - blood Graft vs Host Disease - etiology Graft vs Host Disease - pathology Hematologic and hematopoietic diseases Hematology Hematopoietic Stem Cell Transplantation - adverse effects Humans Leukemia - therapy Male Matrix Metalloproteinase 2 - blood Matrix Metalloproteinase 9 - blood Medical sciences Medicine Medicine & Public Health Middle Aged Oncology Original Article Skin - pathology Transplantation, Homologous Young Adult |
| title | Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T12%3A05%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20serum%20levels%20of%20matrix%20metalloproteinase-9%20in%20acute%20graft-versus-host%20disease%20after%20allogeneic%20haematopoietic%20stem%20cell%20transplantation&rft.jtitle=International%20journal%20of%20hematology&rft.au=Tagami,%20Kozo&rft.date=2009-09-01&rft.volume=90&rft.issue=2&rft.spage=248&rft.epage=252&rft.pages=248-252&rft.issn=0925-5710&rft.eissn=1865-3774&rft_id=info:doi/10.1007/s12185-009-0358-6&rft_dat=%3Cproquest_cross%3E1891669841%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=217376360&rft_id=info:pmid/19548069&rfr_iscdi=true |