Recurrent extramedullary relapse of acute myelogenous leukemia after allogeneic hematopoietic stem cell transplantation in a patient with the chromosomal abnormality t(8;21) and CD56-positivity
Isolated extramedullary (EM) relapse of acute myelogenous leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare. Predisposing factors include CD56 expression and the chromosomal abnormality t(8;21). We describe an AML patient showing the chromosomal abnormality...
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| Veröffentlicht in: | International journal of hematology 2009-10, Vol.90 (3), p.374-377 |
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| container_title | International journal of hematology |
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| creator | Ando, Toshihiko Mitani, Noriyuki Matsui, Kumiko Yamashita, Koji Nomiyama, Jun Tsuru, Masatoshi Yujiri, Toshiaki Tanizawa, Yukio |
| description | Isolated extramedullary (EM) relapse of acute myelogenous leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare. Predisposing factors include CD56 expression and the chromosomal abnormality t(8;21). We describe an AML patient showing the chromosomal abnormality t(8;21) and CD56 expression who experienced a unique EM relapse after allo-HSCT. Approximately 10 months after allo-HSCT, he experienced relapse involving the femur and lumbar vertebrae and, subsequently, an EM relapse of the stomach. Although we administered only local radiotherapy and not systemic chemotherapy, he showed no bone marrow relapse on long-term follow-up after achieving complete hematological remission. These findings suggest that the graft-versus-leukemia effect may preferentially maintain marrow remission rather than prevent EM relapse. In addition, our findings show that extended survival is possible after EM relapse following allo-HSCT in patients with marrow hematopoiesis of donor origin, and that augmentation of the graft-versus-leukemia effect may be useful. |
| doi_str_mv | 10.1007/s12185-009-0385-3 |
| format | Article |
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Predisposing factors include CD56 expression and the chromosomal abnormality t(8;21). We describe an AML patient showing the chromosomal abnormality t(8;21) and CD56 expression who experienced a unique EM relapse after allo-HSCT. Approximately 10 months after allo-HSCT, he experienced relapse involving the femur and lumbar vertebrae and, subsequently, an EM relapse of the stomach. Although we administered only local radiotherapy and not systemic chemotherapy, he showed no bone marrow relapse on long-term follow-up after achieving complete hematological remission. These findings suggest that the graft-versus-leukemia effect may preferentially maintain marrow remission rather than prevent EM relapse. In addition, our findings show that extended survival is possible after EM relapse following allo-HSCT in patients with marrow hematopoiesis of donor origin, and that augmentation of the graft-versus-leukemia effect may be useful.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-009-0385-3</identifier><identifier>PMID: 19629629</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Biological and medical sciences ; Case Report ; CD56 Antigen - metabolism ; Chromosome aberrations ; Chromosomes, Human, Pair 21 ; Chromosomes, Human, Pair 8 ; Gastric Mucosa - pathology ; Graft vs Leukemia Effect ; Hematologic and hematopoietic diseases ; Hematology ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia, Myeloid, Acute - genetics ; Leukemia, Myeloid, Acute - pathology ; Leukemia, Myeloid, Acute - therapy ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical genetics ; Medical sciences ; Medicine ; Medicine & Public Health ; Oncology ; Recurrence ; Stomach Neoplasms - genetics ; Stomach Neoplasms - pathology ; Stomach Neoplasms - therapy ; Translocation, Genetic ; Transplantation, Homologous ; Young Adult</subject><ispartof>International journal of hematology, 2009-10, Vol.90 (3), p.374-377</ispartof><rights>The Japanese Society of Hematology 2009</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-71ed346081953fd6edaa7363886655d3ba8cf1ccdb5caee7baaac35f8be904423</citedby><cites>FETCH-LOGICAL-c549t-71ed346081953fd6edaa7363886655d3ba8cf1ccdb5caee7baaac35f8be904423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12185-009-0385-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12185-009-0385-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22200094$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19629629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ando, Toshihiko</creatorcontrib><creatorcontrib>Mitani, Noriyuki</creatorcontrib><creatorcontrib>Matsui, Kumiko</creatorcontrib><creatorcontrib>Yamashita, Koji</creatorcontrib><creatorcontrib>Nomiyama, Jun</creatorcontrib><creatorcontrib>Tsuru, Masatoshi</creatorcontrib><creatorcontrib>Yujiri, Toshiaki</creatorcontrib><creatorcontrib>Tanizawa, Yukio</creatorcontrib><title>Recurrent extramedullary relapse of acute myelogenous leukemia after allogeneic hematopoietic stem cell transplantation in a patient with the chromosomal abnormality t(8;21) and CD56-positivity</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>Isolated extramedullary (EM) relapse of acute myelogenous leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare. Predisposing factors include CD56 expression and the chromosomal abnormality t(8;21). We describe an AML patient showing the chromosomal abnormality t(8;21) and CD56 expression who experienced a unique EM relapse after allo-HSCT. Approximately 10 months after allo-HSCT, he experienced relapse involving the femur and lumbar vertebrae and, subsequently, an EM relapse of the stomach. Although we administered only local radiotherapy and not systemic chemotherapy, he showed no bone marrow relapse on long-term follow-up after achieving complete hematological remission. These findings suggest that the graft-versus-leukemia effect may preferentially maintain marrow remission rather than prevent EM relapse. In addition, our findings show that extended survival is possible after EM relapse following allo-HSCT in patients with marrow hematopoiesis of donor origin, and that augmentation of the graft-versus-leukemia effect may be useful.</description><subject>Biological and medical sciences</subject><subject>Case Report</subject><subject>CD56 Antigen - metabolism</subject><subject>Chromosome aberrations</subject><subject>Chromosomes, Human, Pair 21</subject><subject>Chromosomes, Human, Pair 8</subject><subject>Gastric Mucosa - pathology</subject><subject>Graft vs Leukemia Effect</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Leukemia, Myeloid, Acute - therapy</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. 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Predisposing factors include CD56 expression and the chromosomal abnormality t(8;21). We describe an AML patient showing the chromosomal abnormality t(8;21) and CD56 expression who experienced a unique EM relapse after allo-HSCT. Approximately 10 months after allo-HSCT, he experienced relapse involving the femur and lumbar vertebrae and, subsequently, an EM relapse of the stomach. Although we administered only local radiotherapy and not systemic chemotherapy, he showed no bone marrow relapse on long-term follow-up after achieving complete hematological remission. These findings suggest that the graft-versus-leukemia effect may preferentially maintain marrow remission rather than prevent EM relapse. In addition, our findings show that extended survival is possible after EM relapse following allo-HSCT in patients with marrow hematopoiesis of donor origin, and that augmentation of the graft-versus-leukemia effect may be useful.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>19629629</pmid><doi>10.1007/s12185-009-0385-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | International journal of hematology, 2009-10, Vol.90 (3), p.374-377 |
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| subjects | Biological and medical sciences Case Report CD56 Antigen - metabolism Chromosome aberrations Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 8 Gastric Mucosa - pathology Graft vs Leukemia Effect Hematologic and hematopoietic diseases Hematology Hematopoietic Stem Cell Transplantation Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical genetics Medical sciences Medicine Medicine & Public Health Oncology Recurrence Stomach Neoplasms - genetics Stomach Neoplasms - pathology Stomach Neoplasms - therapy Translocation, Genetic Transplantation, Homologous Young Adult |
| title | Recurrent extramedullary relapse of acute myelogenous leukemia after allogeneic hematopoietic stem cell transplantation in a patient with the chromosomal abnormality t(8;21) and CD56-positivity |
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