Ecstasy: Are animal data consistent between species and can they translate to humans?

The number of 3,4-methylenedioxymethamphetamine (ecstasy or MDMA) animal research articles is rapidly increasing and yet studies which place emphasis on the clinical signi.cance are limited due to a lack of reliable human data. MDMA produces an acute, rapid release of brain serotonin and dopamine in...

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Veröffentlicht in:	Journal of Psychopharmacology 2006-03, Vol.20 (2), p.194-210
Hauptverfasser:	Easton, Neil, Marsden, Charles A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine-Related Disorders - physiopathology Animals Arousal - drug effects Arousal - physiology Biological and medical sciences Body Temperature Regulation - drug effects Body Temperature Regulation - physiology Brain - drug effects Brain - physiopathology Disease Models, Animal Dopamine Dopamine - metabolism Dopamine receptors Dosage and administration Drugs Ecstasy Ecstasy (Drug) Electrocardiography - drug effects Hallucinogens - toxicity Health aspects Hemodynamics - drug effects Hemodynamics - physiology Human behavior Humans Hyperthermia Locomotor activity MDMA Medical sciences Metabolites Mice N-Methyl-3,4-methylenedioxyamphetamine - toxicity Neuropharmacology Neurotoxicity Pharmacology. Drug treatments Physiological effects Primates Rats Rodents Serotonin Serotonin - metabolism Serotonin Agents - toxicity Serotonin Plasma Membrane Transport Proteins - drug effects Serotonin Plasma Membrane Transport Proteins - physiology Species Specificity User groups
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