Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection

3β‐Hydroxy‐lup‐20(29)‐en‐28‐oic acid (betulinic acid) is a pentacyclic lupane‐type triterpene that is widely distributed throughout the plant kingdom. A variety of biological activities have been ascribed to betulinic acid including anti‐inflammatory and in vitro antimalarial effects. However, betul...

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Veröffentlicht in:	Medicinal research reviews 2004-01, Vol.24 (1), p.90-114
Hauptverfasser:	Cichewicz, Robert H., Kouzi, Samir A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology anti-inflammatory Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology betulin betulinic acid cancer HIV HIV Infections - drug therapy Human immunodeficiency virus Human immunodeficiency virus 1 Humans Mass Spectrometry Neoplasms - drug therapy Neoplasms - prevention & control pentacyclic lupane-type triterpene synthesis Triterpenes - chemical synthesis Triterpenes - chemistry Triterpenes - pharmacology
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