Impaired kidney function and cerebral microbleeds in patients with acute ischemic stroke
We investigated the association between the presence of cerebral microbleeds and poor kidney function in patients with acute ischemic stroke. We retrospectively examined consecutive acute ischemic stroke patients who underwent gradient echo MRI. The presence of cerebral microbleeds on gradient echo...
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| Veröffentlicht in: | Neurology 2009-11, Vol.73 (20), p.1645-1648 |
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| creator | CHO, A.-H LEE, S. B HAN, S. J SHON, Y.-M YANG, D.-W KIM, B. S |
| description | We investigated the association between the presence of cerebral microbleeds and poor kidney function in patients with acute ischemic stroke.
We retrospectively examined consecutive acute ischemic stroke patients who underwent gradient echo MRI. The presence of cerebral microbleeds on gradient echo MRI was independently interpreted. The number and location of microbleeds were assessed. Demographics including age, sex, risk factors, and stroke subtype were obtained. Kidney function was estimated by measuring glomerular filtration rate (GFR) with the modification of diet in renal disease method.
Of the 152 patients included, 45 (29.6%) patients had cerebral microbleeds on gradient echo MRI. The cerebral microbleeds were most commonly located in deep or infratentorial location (27/45 [60%]). Hypertension, presence of leukoaraiosis, old age, and low GFR were associated with the presence of cerebral microbleeds (p = 0.064, |
| doi_str_mv | 10.1212/WNL.0b013e3181c1defa |
| format | Article |
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We retrospectively examined consecutive acute ischemic stroke patients who underwent gradient echo MRI. The presence of cerebral microbleeds on gradient echo MRI was independently interpreted. The number and location of microbleeds were assessed. Demographics including age, sex, risk factors, and stroke subtype were obtained. Kidney function was estimated by measuring glomerular filtration rate (GFR) with the modification of diet in renal disease method.
Of the 152 patients included, 45 (29.6%) patients had cerebral microbleeds on gradient echo MRI. The cerebral microbleeds were most commonly located in deep or infratentorial location (27/45 [60%]). Hypertension, presence of leukoaraiosis, old age, and low GFR were associated with the presence of cerebral microbleeds (p = 0.064, <0.001, 0.014, and <0.001). The mean GFR levels were lower in patients with cerebral microbleeds (65.15 +/- 22.54 vs 78.82 +/- 19.11 mL/min/1.73 m(2)). After the adjustment of risk factors, age, and sex, low GFR levels were associated with the presence of cerebral microbleeds (odds ratio, 3.85; 95% confidence interval, 1.52 to 9.76, p = 0.004).
Impaired kidney function is associated with the presence of cerebral microbleeds in acute ischemic stroke.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.0b013e3181c1defa</identifier><identifier>PMID: 19917986</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Acute Disease ; Age Factors ; Aged ; Biological and medical sciences ; Brain - blood supply ; Brain - pathology ; Brain Ischemia - complications ; Brain Ischemia - epidemiology ; Brain Ischemia - pathology ; Cerebral Hemorrhage - complications ; Cerebral Hemorrhage - epidemiology ; Cerebral Hemorrhage - pathology ; Diabetes Complications ; Female ; Glomerular Filtration Rate ; Humans ; Hyperlipidemias - complications ; Hypertension - complications ; Kidney Diseases - complications ; Kidney Diseases - epidemiology ; Kidney Diseases - physiopathology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Neurology ; Retrospective Studies ; Risk Factors ; Smoking ; Stroke - epidemiology ; Stroke - pathology ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Neurology, 2009-11, Vol.73 (20), p.1645-1648</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-237ea26164506c787201d77a05e48e33bc2bb6238232b25c2c5d5d1fda1117ae3</citedby><cites>FETCH-LOGICAL-c368t-237ea26164506c787201d77a05e48e33bc2bb6238232b25c2c5d5d1fda1117ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22149612$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19917986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHO, A.-H</creatorcontrib><creatorcontrib>LEE, S. B</creatorcontrib><creatorcontrib>HAN, S. J</creatorcontrib><creatorcontrib>SHON, Y.-M</creatorcontrib><creatorcontrib>YANG, D.-W</creatorcontrib><creatorcontrib>KIM, B. S</creatorcontrib><title>Impaired kidney function and cerebral microbleeds in patients with acute ischemic stroke</title><title>Neurology</title><addtitle>Neurology</addtitle><description>We investigated the association between the presence of cerebral microbleeds and poor kidney function in patients with acute ischemic stroke.
We retrospectively examined consecutive acute ischemic stroke patients who underwent gradient echo MRI. The presence of cerebral microbleeds on gradient echo MRI was independently interpreted. The number and location of microbleeds were assessed. Demographics including age, sex, risk factors, and stroke subtype were obtained. Kidney function was estimated by measuring glomerular filtration rate (GFR) with the modification of diet in renal disease method.
Of the 152 patients included, 45 (29.6%) patients had cerebral microbleeds on gradient echo MRI. The cerebral microbleeds were most commonly located in deep or infratentorial location (27/45 [60%]). Hypertension, presence of leukoaraiosis, old age, and low GFR were associated with the presence of cerebral microbleeds (p = 0.064, <0.001, 0.014, and <0.001). The mean GFR levels were lower in patients with cerebral microbleeds (65.15 +/- 22.54 vs 78.82 +/- 19.11 mL/min/1.73 m(2)). After the adjustment of risk factors, age, and sex, low GFR levels were associated with the presence of cerebral microbleeds (odds ratio, 3.85; 95% confidence interval, 1.52 to 9.76, p = 0.004).
Impaired kidney function is associated with the presence of cerebral microbleeds in acute ischemic stroke.</description><subject>Acute Disease</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain - blood supply</subject><subject>Brain - pathology</subject><subject>Brain Ischemia - complications</subject><subject>Brain Ischemia - epidemiology</subject><subject>Brain Ischemia - pathology</subject><subject>Cerebral Hemorrhage - complications</subject><subject>Cerebral Hemorrhage - epidemiology</subject><subject>Cerebral Hemorrhage - pathology</subject><subject>Diabetes Complications</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Hyperlipidemias - complications</subject><subject>Hypertension - complications</subject><subject>Kidney Diseases - complications</subject><subject>Kidney Diseases - epidemiology</subject><subject>Kidney Diseases - physiopathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Smoking</subject><subject>Stroke - epidemiology</subject><subject>Stroke - pathology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq2qqCwf_6CqfKl6CnjGie0cK0QBaVUuIPYWOfZE65KPrZ2o4t9jxKpIXDjNYZ53Ph7GvoI4AwQ8f_i9PhOtAEkSDDjw1NlPbAUVqkJJ3HxmKyHQFNJoc8iOUvojRG7q-gs7hLoGXRu1YpubYWdDJM8fgx_piXfL6OYwjdyOnjuK1Ebb8yG4OLU9kU88jHxn50DjnPi_MG-5dctMPCS3pczxNMfpkU7YQWf7RKf7eszuf13eXVwX69urm4uf68JJZeYCpSaLClRZCeW00SjAa21FRaUhKVuHbatQGpTYYuXQVb7y0HkLANqSPGY_Xufu4vR3oTQ3Q76E-t6ONC2p0WWlUYNUH5OyhLLMyjJZvpL56ZQidc0uhsHGpwZE8yK_yfKb9_Jz7Nt-wdIO5N9Ce9sZ-L4HbHK276IdXUj_OUQoawUonwGP5I7j</recordid><startdate>20091117</startdate><enddate>20091117</enddate><creator>CHO, A.-H</creator><creator>LEE, S. B</creator><creator>HAN, S. J</creator><creator>SHON, Y.-M</creator><creator>YANG, D.-W</creator><creator>KIM, B. S</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20091117</creationdate><title>Impaired kidney function and cerebral microbleeds in patients with acute ischemic stroke</title><author>CHO, A.-H ; LEE, S. B ; HAN, S. J ; SHON, Y.-M ; YANG, D.-W ; KIM, B. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-237ea26164506c787201d77a05e48e33bc2bb6238232b25c2c5d5d1fda1117ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acute Disease</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain - blood supply</topic><topic>Brain - pathology</topic><topic>Brain Ischemia - complications</topic><topic>Brain Ischemia - epidemiology</topic><topic>Brain Ischemia - pathology</topic><topic>Cerebral Hemorrhage - complications</topic><topic>Cerebral Hemorrhage - epidemiology</topic><topic>Cerebral Hemorrhage - pathology</topic><topic>Diabetes Complications</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Hyperlipidemias - complications</topic><topic>Hypertension - complications</topic><topic>Kidney Diseases - complications</topic><topic>Kidney Diseases - epidemiology</topic><topic>Kidney Diseases - physiopathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Smoking</topic><topic>Stroke - epidemiology</topic><topic>Stroke - pathology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHO, A.-H</creatorcontrib><creatorcontrib>LEE, S. B</creatorcontrib><creatorcontrib>HAN, S. J</creatorcontrib><creatorcontrib>SHON, Y.-M</creatorcontrib><creatorcontrib>YANG, D.-W</creatorcontrib><creatorcontrib>KIM, B. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHO, A.-H</au><au>LEE, S. B</au><au>HAN, S. J</au><au>SHON, Y.-M</au><au>YANG, D.-W</au><au>KIM, B. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired kidney function and cerebral microbleeds in patients with acute ischemic stroke</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2009-11-17</date><risdate>2009</risdate><volume>73</volume><issue>20</issue><spage>1645</spage><epage>1648</epage><pages>1645-1648</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>We investigated the association between the presence of cerebral microbleeds and poor kidney function in patients with acute ischemic stroke.
We retrospectively examined consecutive acute ischemic stroke patients who underwent gradient echo MRI. The presence of cerebral microbleeds on gradient echo MRI was independently interpreted. The number and location of microbleeds were assessed. Demographics including age, sex, risk factors, and stroke subtype were obtained. Kidney function was estimated by measuring glomerular filtration rate (GFR) with the modification of diet in renal disease method.
Of the 152 patients included, 45 (29.6%) patients had cerebral microbleeds on gradient echo MRI. The cerebral microbleeds were most commonly located in deep or infratentorial location (27/45 [60%]). Hypertension, presence of leukoaraiosis, old age, and low GFR were associated with the presence of cerebral microbleeds (p = 0.064, <0.001, 0.014, and <0.001). The mean GFR levels were lower in patients with cerebral microbleeds (65.15 +/- 22.54 vs 78.82 +/- 19.11 mL/min/1.73 m(2)). After the adjustment of risk factors, age, and sex, low GFR levels were associated with the presence of cerebral microbleeds (odds ratio, 3.85; 95% confidence interval, 1.52 to 9.76, p = 0.004).
Impaired kidney function is associated with the presence of cerebral microbleeds in acute ischemic stroke.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>19917986</pmid><doi>10.1212/WNL.0b013e3181c1defa</doi><tpages>4</tpages></addata></record> |
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| subjects | Acute Disease Age Factors Aged Biological and medical sciences Brain - blood supply Brain - pathology Brain Ischemia - complications Brain Ischemia - epidemiology Brain Ischemia - pathology Cerebral Hemorrhage - complications Cerebral Hemorrhage - epidemiology Cerebral Hemorrhage - pathology Diabetes Complications Female Glomerular Filtration Rate Humans Hyperlipidemias - complications Hypertension - complications Kidney Diseases - complications Kidney Diseases - epidemiology Kidney Diseases - physiopathology Magnetic Resonance Imaging Male Medical sciences Neurology Retrospective Studies Risk Factors Smoking Stroke - epidemiology Stroke - pathology Vascular diseases and vascular malformations of the nervous system |
| title | Impaired kidney function and cerebral microbleeds in patients with acute ischemic stroke |
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