Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats
Mangiferin (2-β- d-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone) is a xanthone widely distributed in higher plants showing antioxidative, antiviral, anticancer, antidiabetic, immunomodulatory, hepatoprotective, and analgesic effects. In the present study, we have investigated the effects of systemic...
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| Veröffentlicht in: | European journal of pharmacology 2010-06, Vol.635 (1), p.124-128 |
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| creator | Pardo Andreu, Gilberto L. Maurmann, Natasha Reolon, Gustavo Kellermann de Farias, Caroline B. Schwartsmann, Gilberto Delgado, René Roesler, Rafael |
| description | Mangiferin (2-β-
d-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone) is a xanthone widely distributed in higher plants showing antioxidative, antiviral, anticancer, antidiabetic, immunomodulatory, hepatoprotective, and analgesic effects. In the present study, we have investigated the effects of systemic administration of mangiferin on behavioral outcomes of neurological function in normal rats. A single intraperitoneal injection of mangiferin (10, 50, or 100
mg/kg body weight) enhanced novel object recognition (NOR) memory when given immediately post-training. The administration of mangiferin 6
h post-training did not affect NOR memory. There were no significant differences between groups in the total time exploring both objects, indicating that mangiferin did not affect locomotion or motivation. Mangiferin stimulated cell proliferation and induced a significant increase in the supernatant levels of nerve growth factor (NGF) and tumor necrosis factor (TNF)-
α in vitro in human U138-MG glioblastoma cells. The results indicate that mangiferin enhances recognition memory through a mechanism that might involve an increase in neurotrophin and cytokine levels. |
| doi_str_mv | 10.1016/j.ejphar.2010.03.011 |
| format | Article |
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d-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone) is a xanthone widely distributed in higher plants showing antioxidative, antiviral, anticancer, antidiabetic, immunomodulatory, hepatoprotective, and analgesic effects. In the present study, we have investigated the effects of systemic administration of mangiferin on behavioral outcomes of neurological function in normal rats. A single intraperitoneal injection of mangiferin (10, 50, or 100
mg/kg body weight) enhanced novel object recognition (NOR) memory when given immediately post-training. The administration of mangiferin 6
h post-training did not affect NOR memory. There were no significant differences between groups in the total time exploring both objects, indicating that mangiferin did not affect locomotion or motivation. Mangiferin stimulated cell proliferation and induced a significant increase in the supernatant levels of nerve growth factor (NGF) and tumor necrosis factor (TNF)-
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d-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone) is a xanthone widely distributed in higher plants showing antioxidative, antiviral, anticancer, antidiabetic, immunomodulatory, hepatoprotective, and analgesic effects. In the present study, we have investigated the effects of systemic administration of mangiferin on behavioral outcomes of neurological function in normal rats. A single intraperitoneal injection of mangiferin (10, 50, or 100
mg/kg body weight) enhanced novel object recognition (NOR) memory when given immediately post-training. The administration of mangiferin 6
h post-training did not affect NOR memory. There were no significant differences between groups in the total time exploring both objects, indicating that mangiferin did not affect locomotion or motivation. Mangiferin stimulated cell proliferation and induced a significant increase in the supernatant levels of nerve growth factor (NGF) and tumor necrosis factor (TNF)-
α in vitro in human U138-MG glioblastoma cells. The results indicate that mangiferin enhances recognition memory through a mechanism that might involve an increase in neurotrophin and cytokine levels.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Biological Products - administration & dosage</subject><subject>Biological Products - pharmacology</subject><subject>Brain - cytology</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain - physiology</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Mangiferin</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Nerve growth factor</subject><subject>Nerve Growth Factors - metabolism</subject><subject>Object recognition</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Recognition (Psychology) - drug effects</subject><subject>Recognition (Psychology) - physiology</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Xanthones - administration & dosage</subject><subject>Xanthones - pharmacology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFTEQhYMoznX0H4hkI27sa179yEYYBl8w4kbXIV1d3ZOmO7km6WHuvzfDvepOVwWHr6oO5xDykrM9Z7x5N-9xPtzauBesSEzuGeePyI53ra5Yy8VjsmOMq0porS_Is5RmxlitRf2UXAgmmdSy3pHpq_WTGzE6_5Za6m3eol2WIw0AWyzqRKdlg3Dvlnvr823wSN16iOEOE12Cn6qMcaWhnxEyjQhh8i674OmKa4hH6jyNNqfn5Mlol4QvzvOS_Pj44fv15-rm26cv11c3FSghc9W3yAVw2dRj13V27GvRNmIcLYCwiHzsQXHsO6lADh3jUqt2UPWgNNSgByUvyZvT3WLx54Ypm9UlwGWxHsOWTKvqVjRctf8nZUmo3O8KqU4kxJBSxNEcolttPBrOzEMXZjanLsxDF4ZJU7ooa6_OD7Z-xeHP0u_wC_D6DNgEdhmj9eDSX060uhGdKNz7E4cluDuH0SRw6AEHVwLPZgju305-AT2Fq3I</recordid><startdate>20100610</startdate><enddate>20100610</enddate><creator>Pardo Andreu, Gilberto L.</creator><creator>Maurmann, Natasha</creator><creator>Reolon, Gustavo Kellermann</creator><creator>de Farias, Caroline B.</creator><creator>Schwartsmann, Gilberto</creator><creator>Delgado, René</creator><creator>Roesler, Rafael</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20100610</creationdate><title>Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats</title><author>Pardo Andreu, Gilberto L. ; Maurmann, Natasha ; Reolon, Gustavo Kellermann ; de Farias, Caroline B. ; Schwartsmann, Gilberto ; Delgado, René ; Roesler, Rafael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-b7e12c1365f888afb52762ffacc2aee1fbc41eb834c3d8013947d45d49c5c9d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Biological Products - administration & dosage</topic><topic>Biological Products - pharmacology</topic><topic>Brain - cytology</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain - physiology</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Mangiferin</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Nerve growth factor</topic><topic>Nerve Growth Factors - metabolism</topic><topic>Object recognition</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Recognition (Psychology) - drug effects</topic><topic>Recognition (Psychology) - physiology</topic><topic>Tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Xanthones - administration & dosage</topic><topic>Xanthones - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pardo Andreu, Gilberto L.</creatorcontrib><creatorcontrib>Maurmann, Natasha</creatorcontrib><creatorcontrib>Reolon, Gustavo Kellermann</creatorcontrib><creatorcontrib>de Farias, Caroline B.</creatorcontrib><creatorcontrib>Schwartsmann, Gilberto</creatorcontrib><creatorcontrib>Delgado, René</creatorcontrib><creatorcontrib>Roesler, Rafael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pardo Andreu, Gilberto L.</au><au>Maurmann, Natasha</au><au>Reolon, Gustavo Kellermann</au><au>de Farias, Caroline B.</au><au>Schwartsmann, Gilberto</au><au>Delgado, René</au><au>Roesler, Rafael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2010-06-10</date><risdate>2010</risdate><volume>635</volume><issue>1</issue><spage>124</spage><epage>128</epage><pages>124-128</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Mangiferin (2-β-
d-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone) is a xanthone widely distributed in higher plants showing antioxidative, antiviral, anticancer, antidiabetic, immunomodulatory, hepatoprotective, and analgesic effects. In the present study, we have investigated the effects of systemic administration of mangiferin on behavioral outcomes of neurological function in normal rats. A single intraperitoneal injection of mangiferin (10, 50, or 100
mg/kg body weight) enhanced novel object recognition (NOR) memory when given immediately post-training. The administration of mangiferin 6
h post-training did not affect NOR memory. There were no significant differences between groups in the total time exploring both objects, indicating that mangiferin did not affect locomotion or motivation. Mangiferin stimulated cell proliferation and induced a significant increase in the supernatant levels of nerve growth factor (NGF) and tumor necrosis factor (TNF)-
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| subjects | Animals Behavior, Animal - drug effects Biological and medical sciences Biological Products - administration & dosage Biological Products - pharmacology Brain - cytology Brain - drug effects Brain - metabolism Brain - physiology Cell Line, Tumor Cell Proliferation - drug effects Humans Male Mangiferin Medical sciences Memory Nerve growth factor Nerve Growth Factors - metabolism Object recognition Pharmacology. Drug treatments Rats Rats, Wistar Recognition (Psychology) - drug effects Recognition (Psychology) - physiology Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Xanthones - administration & dosage Xanthones - pharmacology |
| title | Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats |
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