The orexin system: roles in sleep/wake regulation
The neuropeptides orexin A and orexin B, produced in hypothalamic neurons, are critical regulators of sleep/wake states. Deficiency of orexin signaling results in narcoleptic phenotype in humans, dogs, and rodents. Recently, accumulating evidence has indicated that the orexin system regulates sleep...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2010-07, Vol.1200 (1), p.149-161 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | Sakurai, Takeshi Mieda, Michihiro Tsujino, Natsuko |
| description | The neuropeptides orexin A and orexin B, produced in hypothalamic neurons, are critical regulators of sleep/wake states. Deficiency of orexin signaling results in narcoleptic phenotype in humans, dogs, and rodents. Recently, accumulating evidence has indicated that the orexin system regulates sleep and wakefulness through interactions with neuronal systems that are closely related with emotion, reward, and energy homeostasis. In this review, we will discuss the current understanding of the physiology of the orexin system especially focusing on its roles in the regulation of sleep/wakefulness states. |
| doi_str_mv | 10.1111/j.1749-6632.2010.05513.x |
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| ispartof | Annals of the New York Academy of Sciences, 2010-07, Vol.1200 (1), p.149-161 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Emotions Energy Metabolism Homeostasis Humans hypothalamus Intracellular Signaling Peptides and Proteins - physiology Motivation narcolepsy Neuropeptides - physiology orexin Orexins Sleep Sleep - physiology wakefulness Wakefulness - physiology |
| title | The orexin system: roles in sleep/wake regulation |
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