Environmental factors and genetic susceptibility promote urinary bladder cancer
Cancer of the urinary bladder is the second most common malignancy of the genitourinary tract, currently accounting for up to 5% of all newly diagnosed tumours in the western world. Urinary bladder carcinogenesis seems to develop from the interaction of environmental exposure and genetic susceptibil...
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| Veröffentlicht in: | Toxicology letters 2010-03, Vol.193 (2), p.131-137 |
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| container_title | Toxicology letters |
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| creator | Volanis, Dimitrios Kadiyska, Tanya Galanis, Alex Delakas, Dimitrios Logotheti, Stella Zoumpourlis, Vassilis |
| description | Cancer of the urinary bladder is the second most common malignancy of the genitourinary tract, currently accounting for up to 5% of all newly diagnosed tumours in the western world. Urinary bladder carcinogenesis seems to develop from the interaction of environmental exposure and genetic susceptibility. Smoking, specific industrial chemicals, dietary nitrates and arsenic represent the most important exogenous risk factors. Chromosomal abnormalities, silencing of certain genes by abnormal methylation of their promoter region, alterations in tumour suppressor genes and proto-oncogenes that induce uncontrolled cell proliferation and reduced apoptosis, are molecular mechanisms that have been reported in bladder carcinogenesis. In this article, we discuss the environmental risk factors of bladder cancer and we review the genetic and epigenetic alterations, including aberrant DNA methylation and deregulation of microRNAs expression. We also discuss the role of p53 and retinoblastoma suppressor genes in disease progression. Finally, we present recent reports on the use of molecular profiling to predict disease stage and grade and direct targeted therapy. |
| doi_str_mv | 10.1016/j.toxlet.2009.12.018 |
| format | Article |
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Urinary bladder carcinogenesis seems to develop from the interaction of environmental exposure and genetic susceptibility. Smoking, specific industrial chemicals, dietary nitrates and arsenic represent the most important exogenous risk factors. Chromosomal abnormalities, silencing of certain genes by abnormal methylation of their promoter region, alterations in tumour suppressor genes and proto-oncogenes that induce uncontrolled cell proliferation and reduced apoptosis, are molecular mechanisms that have been reported in bladder carcinogenesis. In this article, we discuss the environmental risk factors of bladder cancer and we review the genetic and epigenetic alterations, including aberrant DNA methylation and deregulation of microRNAs expression. We also discuss the role of p53 and retinoblastoma suppressor genes in disease progression. Finally, we present recent reports on the use of molecular profiling to predict disease stage and grade and direct targeted therapy.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/j.toxlet.2009.12.018</identifier><identifier>PMID: 20051252</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Bladder cancer ; Chromosome Aberrations ; Disease Progression ; DNA Methylation ; Environment. Living conditions ; Environmental Exposure ; Environmental risk factor ; Gene Expression Profiling ; Genes, p53 ; Genes, Retinoblastoma ; Genetic polymorphism ; Genetic Predisposition to Disease - genetics ; Humans ; Medical sciences ; MicroRNAs - metabolism ; miRNAs ; Molecular profiling ; Nephrology. Urinary tract diseases ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Toxicology ; Tumors of the urinary system ; Urinary Bladder Neoplasms - diagnosis ; Urinary Bladder Neoplasms - etiology ; Urinary Bladder Neoplasms - genetics ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland</subject><ispartof>Toxicology letters, 2010-03, Vol.193 (2), p.131-137</ispartof><rights>2010 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-d928fb7008ec8006f9229a7539446665f3fdf4dc4729cbdb08159f0c817e16473</citedby><cites>FETCH-LOGICAL-c423t-d928fb7008ec8006f9229a7539446665f3fdf4dc4729cbdb08159f0c817e16473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.toxlet.2009.12.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22519664$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20051252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Volanis, Dimitrios</creatorcontrib><creatorcontrib>Kadiyska, Tanya</creatorcontrib><creatorcontrib>Galanis, Alex</creatorcontrib><creatorcontrib>Delakas, Dimitrios</creatorcontrib><creatorcontrib>Logotheti, Stella</creatorcontrib><creatorcontrib>Zoumpourlis, Vassilis</creatorcontrib><title>Environmental factors and genetic susceptibility promote urinary bladder cancer</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>Cancer of the urinary bladder is the second most common malignancy of the genitourinary tract, currently accounting for up to 5% of all newly diagnosed tumours in the western world. Urinary bladder carcinogenesis seems to develop from the interaction of environmental exposure and genetic susceptibility. Smoking, specific industrial chemicals, dietary nitrates and arsenic represent the most important exogenous risk factors. Chromosomal abnormalities, silencing of certain genes by abnormal methylation of their promoter region, alterations in tumour suppressor genes and proto-oncogenes that induce uncontrolled cell proliferation and reduced apoptosis, are molecular mechanisms that have been reported in bladder carcinogenesis. In this article, we discuss the environmental risk factors of bladder cancer and we review the genetic and epigenetic alterations, including aberrant DNA methylation and deregulation of microRNAs expression. We also discuss the role of p53 and retinoblastoma suppressor genes in disease progression. Finally, we present recent reports on the use of molecular profiling to predict disease stage and grade and direct targeted therapy.</description><subject>Biological and medical sciences</subject><subject>Bladder cancer</subject><subject>Chromosome Aberrations</subject><subject>Disease Progression</subject><subject>DNA Methylation</subject><subject>Environment. Living conditions</subject><subject>Environmental Exposure</subject><subject>Environmental risk factor</subject><subject>Gene Expression Profiling</subject><subject>Genes, p53</subject><subject>Genes, Retinoblastoma</subject><subject>Genetic polymorphism</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>MicroRNAs - metabolism</subject><subject>miRNAs</subject><subject>Molecular profiling</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Toxicology</subject><subject>Tumors of the urinary system</subject><subject>Urinary Bladder Neoplasms - diagnosis</subject><subject>Urinary Bladder Neoplasms - etiology</subject><subject>Urinary Bladder Neoplasms - genetics</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOxCAYRonR6Hh5A2O6Ma5agVIoGxNjxkti4kbXhMKPYdLLCNTo24uZUXeu2JwPDgehU4Irggm_XFVp-ughVRRjWRFaYdLuoAVphSxrwuUuWuBatCWjgh2gwxhXGGPOeLOPDvKkIbShC_S0HN99mMYBxqT7wmmTphALPdriFUZI3hRxjgbWyXe-9-mzWIdpmBIUc_CjDp9F12trIRRGjwbCMdpzuo9wsj2P0Mvt8vnmvnx8unu4uX4sDaN1Kq2kresExi2YNms5SanUoqklY5zzxtXOOmYNE1Sazna4JY102LREAOFM1EfoYnNv1nmbISY1-KzZ93qEaY5KsEaQmjCZSbYhTZhiDODUOvghmyuC1XdJtVKbkuq7pCJU5ZJ5drZ9YO4GsL-jn3QZON8COhrdu5D_7-MfRxsiOWeZu9pwkHO8ewgqGg-5lfUBTFJ28v-bfAFoQZQl</recordid><startdate>20100315</startdate><enddate>20100315</enddate><creator>Volanis, Dimitrios</creator><creator>Kadiyska, Tanya</creator><creator>Galanis, Alex</creator><creator>Delakas, Dimitrios</creator><creator>Logotheti, Stella</creator><creator>Zoumpourlis, Vassilis</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20100315</creationdate><title>Environmental factors and genetic susceptibility promote urinary bladder cancer</title><author>Volanis, Dimitrios ; Kadiyska, Tanya ; Galanis, Alex ; Delakas, Dimitrios ; Logotheti, Stella ; Zoumpourlis, Vassilis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-d928fb7008ec8006f9229a7539446665f3fdf4dc4729cbdb08159f0c817e16473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Bladder cancer</topic><topic>Chromosome Aberrations</topic><topic>Disease Progression</topic><topic>DNA Methylation</topic><topic>Environment. Living conditions</topic><topic>Environmental Exposure</topic><topic>Environmental risk factor</topic><topic>Gene Expression Profiling</topic><topic>Genes, p53</topic><topic>Genes, Retinoblastoma</topic><topic>Genetic polymorphism</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>MicroRNAs - metabolism</topic><topic>miRNAs</topic><topic>Molecular profiling</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Toxicology</topic><topic>Tumors of the urinary system</topic><topic>Urinary Bladder Neoplasms - diagnosis</topic><topic>Urinary Bladder Neoplasms - etiology</topic><topic>Urinary Bladder Neoplasms - genetics</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Volanis, Dimitrios</creatorcontrib><creatorcontrib>Kadiyska, Tanya</creatorcontrib><creatorcontrib>Galanis, Alex</creatorcontrib><creatorcontrib>Delakas, Dimitrios</creatorcontrib><creatorcontrib>Logotheti, Stella</creatorcontrib><creatorcontrib>Zoumpourlis, Vassilis</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Volanis, Dimitrios</au><au>Kadiyska, Tanya</au><au>Galanis, Alex</au><au>Delakas, Dimitrios</au><au>Logotheti, Stella</au><au>Zoumpourlis, Vassilis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental factors and genetic susceptibility promote urinary bladder cancer</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>2010-03-15</date><risdate>2010</risdate><volume>193</volume><issue>2</issue><spage>131</spage><epage>137</epage><pages>131-137</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>Cancer of the urinary bladder is the second most common malignancy of the genitourinary tract, currently accounting for up to 5% of all newly diagnosed tumours in the western world. 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| ispartof | Toxicology letters, 2010-03, Vol.193 (2), p.131-137 |
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| subjects | Biological and medical sciences Bladder cancer Chromosome Aberrations Disease Progression DNA Methylation Environment. Living conditions Environmental Exposure Environmental risk factor Gene Expression Profiling Genes, p53 Genes, Retinoblastoma Genetic polymorphism Genetic Predisposition to Disease - genetics Humans Medical sciences MicroRNAs - metabolism miRNAs Molecular profiling Nephrology. Urinary tract diseases Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Toxicology Tumors of the urinary system Urinary Bladder Neoplasms - diagnosis Urinary Bladder Neoplasms - etiology Urinary Bladder Neoplasms - genetics Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland |
| title | Environmental factors and genetic susceptibility promote urinary bladder cancer |
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