Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic
Acrylamide (CH 2 CHCONH 2, CAS Registry No. 79-06-1) is an industrial chemical used since the 1950s as a chemical intermediate in the production of polyacrylamides, which are used as flocculants for clarifying drinking-water and other industrial applications. The neurotoxicity of acrylamide in human...
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| Veröffentlicht in: | Food and chemical toxicology 2010, Vol.48, p.S25-S33 |
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| container_title | Food and chemical toxicology |
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| creator | Michael Bolger, P. Leblanc, Jean-Charles Woodrow Setzer, R. |
| description | Acrylamide (CH
2
CHCONH
2, CAS Registry No. 79-06-1) is an industrial chemical used since the 1950s as a chemical intermediate in the production of polyacrylamides, which are used as flocculants for clarifying drinking-water and other industrial applications. The neurotoxicity of acrylamide in humans is well known from occupational and accidental exposures. In addition, experimental studies with acrylamide in animals have shown reproductive, genotoxic and carcinogenic properties. Acrylamide may be formed when foods, particularly those that are high in carbohydrates and low in protein, are subjected to high temperatures during cooking or other thermal processing. |
| doi_str_mv | 10.1016/j.fct.2009.11.040 |
| format | Article |
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2
CHCONH
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CHCONH
2, CAS Registry No. 79-06-1) is an industrial chemical used since the 1950s as a chemical intermediate in the production of polyacrylamides, which are used as flocculants for clarifying drinking-water and other industrial applications. The neurotoxicity of acrylamide in humans is well known from occupational and accidental exposures. In addition, experimental studies with acrylamide in animals have shown reproductive, genotoxic and carcinogenic properties. Acrylamide may be formed when foods, particularly those that are high in carbohydrates and low in protein, are subjected to high temperatures during cooking or other thermal processing.</description><subject>Acrylamide</subject><subject>Carbohydrates</subject><subject>Carcinogens</subject><subject>Foods</subject><subject>Genotoxicity</subject><subject>Heating</subject><subject>Human</subject><subject>Margin of Exposure (MoE)</subject><subject>Polyacrylamides</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PwzAMhiMEEmPwA7jlBhxa7CZtWnGapvEhgbjAOcrywTJtTUk6BP-ewDhzsmw9r2U_hJwjlAjYXK9Lp8eyAuhKxBI4HJAJtoIVDavxkEygEm3RdFgfk5OU1gAgUDQT0s-GYeO1Gn3oaXB0XFn6pOKb_-0Wn0NIu2jp5VNYXFE1DDEovaJjoGm3TKPqtU00sy4Ek7NqpCrTb7YPY_j0mqreUK2i9n3IQ69PyZFTm2TP_uqUvN4uXub3xePz3cN89lhoFJwVlULjWIU175yCytiW16rlYinqlvEGGMCSAzrXVbwxy66pkIkGuDG1ZsZ2bEou9nvzwe87m0a59UnbzUb1NuySFLwWWLXAMol7UseQUrRODtFvVfySCPJHrVzLrFb-qJWIMqvNmZt9xuYXPryNMmlvswvjo82sCf6f9Dc8poC8</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Michael Bolger, P.</creator><creator>Leblanc, Jean-Charles</creator><creator>Woodrow Setzer, R.</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope></search><sort><creationdate>2010</creationdate><title>Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic</title><author>Michael Bolger, P. ; Leblanc, Jean-Charles ; Woodrow Setzer, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1743-2a1df321549fa02de845a847b7583460300b401ff9246db962137604dd5c3de93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acrylamide</topic><topic>Carbohydrates</topic><topic>Carcinogens</topic><topic>Foods</topic><topic>Genotoxicity</topic><topic>Heating</topic><topic>Human</topic><topic>Margin of Exposure (MoE)</topic><topic>Polyacrylamides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Michael Bolger, P.</creatorcontrib><creatorcontrib>Leblanc, Jean-Charles</creatorcontrib><creatorcontrib>Woodrow Setzer, R.</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Michael Bolger, P.</au><au>Leblanc, Jean-Charles</au><au>Woodrow Setzer, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic</atitle><jtitle>Food and chemical toxicology</jtitle><date>2010</date><risdate>2010</risdate><volume>48</volume><spage>S25</spage><epage>S33</epage><pages>S25-S33</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><abstract>Acrylamide (CH
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| issn | 0278-6915 1873-6351 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Acrylamide Carbohydrates Carcinogens Foods Genotoxicity Heating Human Margin of Exposure (MoE) Polyacrylamides |
| title | Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic |
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