The prognostic value of amplitude integrated EEG in neonatal sepsis and/or meningitis
Aim: To investigate the longitudinal course and prognostic value of amplitude integrated EEG (aEEG) in infants with neonatal sepsis or meningitis. Methods: Amplitude integrated EEG recordings of 22 infants with sepsis/meningitis were retrospectively evaluated. Mean gestational age was 38 weeks (ra...
Gespeichert in:
| Veröffentlicht in: | Acta Paediatrica 2010-02, Vol.99 (2), p.194-200 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 200 |
|---|---|
| container_issue | 2 |
| container_start_page | 194 |
| container_title | Acta Paediatrica |
| container_volume | 99 |
| creator | Ter Horst, HJ Van Olffen, M Remmelts, HJ De Vries, H Bos, AF |
| description | Aim: To investigate the longitudinal course and prognostic value of amplitude integrated EEG (aEEG) in infants with neonatal sepsis or meningitis.
Methods: Amplitude integrated EEG recordings of 22 infants with sepsis/meningitis were retrospectively evaluated. Mean gestational age was 38 weeks (range: 34–42 weeks). Thirteen infants had meningitis. Survivors were seen for neurological follow‐up. Four infants died, two were severely abnormal at 24 months. Amplitude integrated EEG background pattern, sleep wake cycling (SWC) and electrographic seizure activity (EA) were appraised.
Results: All infants with continuous low voltage or flat trace on aEEG (n = 4) had an adverse outcome. Low voltage aEEGs (n = 9) had a positive LR (LR+) for an adverse outcome of 5.3 (95% CI: 1.9–14.8) at 6 h and 8.3 (95% CI: 1.3–55) at 24 h after admission. EA was more frequent in infants with adverse outcome (p |
| doi_str_mv | 10.1111/j.1651-2227.2009.01567.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_745711342</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>745711342</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4687-e133a9efe67f6c3c98b6f06832a1d4835d044def5504a330925642c12ee272873</originalsourceid><addsrcrecordid>eNqNkE1vEzEQhi1ERUPgLyBfEKfd-tveA4coCgFUtUFqhcTFcndng8N-BHsX0n-Pl0ThSOcyY837jmcehDAlOU1xtcupkjRjjOmcEVLkhEql88MzNDs3nqMZMYRnkkl-iV7GuCOE8UKoF-iSFsYUlLAZur_7Dngf-m3Xx8GX-JdrRsB9jV27b_wwVoB9N8A2uAEqvFqt0xN30HducA2OsI8-YtdVV33ALXS-2_rBx1foonZNhNenPEf3H1Z3y4_Z9e3603JxnZVCGZ0B5dwVUIPStSp5WZgHVRNlOHO0EobLighRQS0lEY5zUjCpBCspA2CaGc3n6N1xbrrg5whxsK2PJTSNSyuO0WohNaVcsP8rOTdUFSnNkTkqy9DHGKC2--BbFx4tJXaib3d2gmwnyHaib__St4dkfXP6ZHxoofpnPOFOgrcngYula-rgutLHsy5NNEbJ6a73R91v38Djkxewi81iqpI_O_p9HOBw9rvww6aulvbrzdpu5OeN_vZlaRX_A1wZrdM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733816973</pqid></control><display><type>article</type><title>The prognostic value of amplitude integrated EEG in neonatal sepsis and/or meningitis</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Ter Horst, HJ ; Van Olffen, M ; Remmelts, HJ ; De Vries, H ; Bos, AF</creator><creatorcontrib>Ter Horst, HJ ; Van Olffen, M ; Remmelts, HJ ; De Vries, H ; Bos, AF</creatorcontrib><description>Aim: To investigate the longitudinal course and prognostic value of amplitude integrated EEG (aEEG) in infants with neonatal sepsis or meningitis.
Methods: Amplitude integrated EEG recordings of 22 infants with sepsis/meningitis were retrospectively evaluated. Mean gestational age was 38 weeks (range: 34–42 weeks). Thirteen infants had meningitis. Survivors were seen for neurological follow‐up. Four infants died, two were severely abnormal at 24 months. Amplitude integrated EEG background pattern, sleep wake cycling (SWC) and electrographic seizure activity (EA) were appraised.
Results: All infants with continuous low voltage or flat trace on aEEG (n = 4) had an adverse outcome. Low voltage aEEGs (n = 9) had a positive LR (LR+) for an adverse outcome of 5.3 (95% CI: 1.9–14.8) at 6 h and 8.3 (95% CI: 1.3–55) at 24 h after admission. EA was more frequent in infants with adverse outcome (p < 0.01) and had a LR+ for adverse outcome of 10.6 (95% CI: 1.5–76). SWC appeared more frequent in infants with good outcome (p < 0.05).
Conclusion: Low voltage background pattern, SWC and EA on aEEG are helpful to predict neurological outcome in infants with neonatal sepsis or meningitis.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/j.1651-2227.2009.01567.x</identifier><identifier>PMID: 19889102</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Bacterial diseases ; Bacterial sepsis ; Biological and medical sciences ; Cerebral function monitor ; Electroencephalogram ; Electroencephalography - methods ; General aspects ; Gestational Age ; Human bacterial diseases ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - diagnosis ; Infant, Premature, Diseases - physiopathology ; Infectious diseases ; Longitudinal Studies ; Medical sciences ; Meningitis ; Meningitis - diagnosis ; Meningitis - physiopathology ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Seizures ; Sepsis - diagnosis ; Sepsis - physiopathology ; Sleep ; Wakefulness</subject><ispartof>Acta Paediatrica, 2010-02, Vol.99 (2), p.194-200</ispartof><rights>2009 The Author(s)/Journal Compilation © 2009 Foundation Acta Pædiatrica</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4687-e133a9efe67f6c3c98b6f06832a1d4835d044def5504a330925642c12ee272873</citedby><cites>FETCH-LOGICAL-c4687-e133a9efe67f6c3c98b6f06832a1d4835d044def5504a330925642c12ee272873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1651-2227.2009.01567.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1651-2227.2009.01567.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22288657$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19889102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ter Horst, HJ</creatorcontrib><creatorcontrib>Van Olffen, M</creatorcontrib><creatorcontrib>Remmelts, HJ</creatorcontrib><creatorcontrib>De Vries, H</creatorcontrib><creatorcontrib>Bos, AF</creatorcontrib><title>The prognostic value of amplitude integrated EEG in neonatal sepsis and/or meningitis</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Aim: To investigate the longitudinal course and prognostic value of amplitude integrated EEG (aEEG) in infants with neonatal sepsis or meningitis.
Methods: Amplitude integrated EEG recordings of 22 infants with sepsis/meningitis were retrospectively evaluated. Mean gestational age was 38 weeks (range: 34–42 weeks). Thirteen infants had meningitis. Survivors were seen for neurological follow‐up. Four infants died, two were severely abnormal at 24 months. Amplitude integrated EEG background pattern, sleep wake cycling (SWC) and electrographic seizure activity (EA) were appraised.
Results: All infants with continuous low voltage or flat trace on aEEG (n = 4) had an adverse outcome. Low voltage aEEGs (n = 9) had a positive LR (LR+) for an adverse outcome of 5.3 (95% CI: 1.9–14.8) at 6 h and 8.3 (95% CI: 1.3–55) at 24 h after admission. EA was more frequent in infants with adverse outcome (p < 0.01) and had a LR+ for adverse outcome of 10.6 (95% CI: 1.5–76). SWC appeared more frequent in infants with good outcome (p < 0.05).
Conclusion: Low voltage background pattern, SWC and EA on aEEG are helpful to predict neurological outcome in infants with neonatal sepsis or meningitis.</description><subject>Bacterial diseases</subject><subject>Bacterial sepsis</subject><subject>Biological and medical sciences</subject><subject>Cerebral function monitor</subject><subject>Electroencephalogram</subject><subject>Electroencephalography - methods</subject><subject>General aspects</subject><subject>Gestational Age</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - diagnosis</subject><subject>Infant, Premature, Diseases - physiopathology</subject><subject>Infectious diseases</subject><subject>Longitudinal Studies</subject><subject>Medical sciences</subject><subject>Meningitis</subject><subject>Meningitis - diagnosis</subject><subject>Meningitis - physiopathology</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Seizures</subject><subject>Sepsis - diagnosis</subject><subject>Sepsis - physiopathology</subject><subject>Sleep</subject><subject>Wakefulness</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1vEzEQhi1ERUPgLyBfEKfd-tveA4coCgFUtUFqhcTFcndng8N-BHsX0n-Pl0ThSOcyY837jmcehDAlOU1xtcupkjRjjOmcEVLkhEql88MzNDs3nqMZMYRnkkl-iV7GuCOE8UKoF-iSFsYUlLAZur_7Dngf-m3Xx8GX-JdrRsB9jV27b_wwVoB9N8A2uAEqvFqt0xN30HducA2OsI8-YtdVV33ALXS-2_rBx1foonZNhNenPEf3H1Z3y4_Z9e3603JxnZVCGZ0B5dwVUIPStSp5WZgHVRNlOHO0EobLighRQS0lEY5zUjCpBCspA2CaGc3n6N1xbrrg5whxsK2PJTSNSyuO0WohNaVcsP8rOTdUFSnNkTkqy9DHGKC2--BbFx4tJXaib3d2gmwnyHaib__St4dkfXP6ZHxoofpnPOFOgrcngYula-rgutLHsy5NNEbJ6a73R91v38Djkxewi81iqpI_O_p9HOBw9rvww6aulvbrzdpu5OeN_vZlaRX_A1wZrdM</recordid><startdate>201002</startdate><enddate>201002</enddate><creator>Ter Horst, HJ</creator><creator>Van Olffen, M</creator><creator>Remmelts, HJ</creator><creator>De Vries, H</creator><creator>Bos, AF</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7TK</scope><scope>C1K</scope></search><sort><creationdate>201002</creationdate><title>The prognostic value of amplitude integrated EEG in neonatal sepsis and/or meningitis</title><author>Ter Horst, HJ ; Van Olffen, M ; Remmelts, HJ ; De Vries, H ; Bos, AF</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4687-e133a9efe67f6c3c98b6f06832a1d4835d044def5504a330925642c12ee272873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Bacterial diseases</topic><topic>Bacterial sepsis</topic><topic>Biological and medical sciences</topic><topic>Cerebral function monitor</topic><topic>Electroencephalogram</topic><topic>Electroencephalography - methods</topic><topic>General aspects</topic><topic>Gestational Age</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - diagnosis</topic><topic>Infant, Premature, Diseases - physiopathology</topic><topic>Infectious diseases</topic><topic>Longitudinal Studies</topic><topic>Medical sciences</topic><topic>Meningitis</topic><topic>Meningitis - diagnosis</topic><topic>Meningitis - physiopathology</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Seizures</topic><topic>Sepsis - diagnosis</topic><topic>Sepsis - physiopathology</topic><topic>Sleep</topic><topic>Wakefulness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ter Horst, HJ</creatorcontrib><creatorcontrib>Van Olffen, M</creatorcontrib><creatorcontrib>Remmelts, HJ</creatorcontrib><creatorcontrib>De Vries, H</creatorcontrib><creatorcontrib>Bos, AF</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ter Horst, HJ</au><au>Van Olffen, M</au><au>Remmelts, HJ</au><au>De Vries, H</au><au>Bos, AF</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prognostic value of amplitude integrated EEG in neonatal sepsis and/or meningitis</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2010-02</date><risdate>2010</risdate><volume>99</volume><issue>2</issue><spage>194</spage><epage>200</epage><pages>194-200</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>Aim: To investigate the longitudinal course and prognostic value of amplitude integrated EEG (aEEG) in infants with neonatal sepsis or meningitis.
Methods: Amplitude integrated EEG recordings of 22 infants with sepsis/meningitis were retrospectively evaluated. Mean gestational age was 38 weeks (range: 34–42 weeks). Thirteen infants had meningitis. Survivors were seen for neurological follow‐up. Four infants died, two were severely abnormal at 24 months. Amplitude integrated EEG background pattern, sleep wake cycling (SWC) and electrographic seizure activity (EA) were appraised.
Results: All infants with continuous low voltage or flat trace on aEEG (n = 4) had an adverse outcome. Low voltage aEEGs (n = 9) had a positive LR (LR+) for an adverse outcome of 5.3 (95% CI: 1.9–14.8) at 6 h and 8.3 (95% CI: 1.3–55) at 24 h after admission. EA was more frequent in infants with adverse outcome (p < 0.01) and had a LR+ for adverse outcome of 10.6 (95% CI: 1.5–76). SWC appeared more frequent in infants with good outcome (p < 0.05).
Conclusion: Low voltage background pattern, SWC and EA on aEEG are helpful to predict neurological outcome in infants with neonatal sepsis or meningitis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19889102</pmid><doi>10.1111/j.1651-2227.2009.01567.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0803-5253 |
| ispartof | Acta Paediatrica, 2010-02, Vol.99 (2), p.194-200 |
| issn | 0803-5253 1651-2227 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_745711342 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Bacterial diseases Bacterial sepsis Biological and medical sciences Cerebral function monitor Electroencephalogram Electroencephalography - methods General aspects Gestational Age Human bacterial diseases Humans Infant Infant, Newborn Infant, Premature Infant, Premature, Diseases - diagnosis Infant, Premature, Diseases - physiopathology Infectious diseases Longitudinal Studies Medical sciences Meningitis Meningitis - diagnosis Meningitis - physiopathology Predictive Value of Tests Prognosis Retrospective Studies Seizures Sepsis - diagnosis Sepsis - physiopathology Sleep Wakefulness |
| title | The prognostic value of amplitude integrated EEG in neonatal sepsis and/or meningitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T19%3A18%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20prognostic%20value%20of%20amplitude%20integrated%20EEG%20in%20neonatal%20sepsis%20and/or%20meningitis&rft.jtitle=Acta%20Paediatrica&rft.au=Ter%20Horst,%20HJ&rft.date=2010-02&rft.volume=99&rft.issue=2&rft.spage=194&rft.epage=200&rft.pages=194-200&rft.issn=0803-5253&rft.eissn=1651-2227&rft_id=info:doi/10.1111/j.1651-2227.2009.01567.x&rft_dat=%3Cproquest_cross%3E745711342%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733816973&rft_id=info:pmid/19889102&rfr_iscdi=true |