Identification of a novel series of potent RON receptor tyrosine kinase inhibitors

A novel series of N-(3-fluoro-4-(2-substituted-thieno[3,2- b]pyridin-7-yloxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1 H-pyrazole-4-carboxamides targeting RON receptor tyrosine kinase was designed and synthesized. SAR study of the series allowed us to identify compounds possessing either inhibitory act...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-05, Vol.20 (9), p.2745-2749
Hauptverfasser:	Raeppel, Stéphane, Gaudette, Frédéric, Mannion, Michael, Claridge, Stephen, Saavedra, Oscar, Isakovic, Ljubomir, Déziel, Robert, Beaulieu, Normand, Beaulieu, Carole, Dupont, Isabelle, Nguyen, Hannah, Wang, James, Macleod, A. Robert, Maroun, Christiane, Besterman, Jeffrey M., Vaisburg, Arkadii
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Biological and medical sciences c-Met Cell Line, Tumor General aspects Heterocyclic Compounds, 2-Ring - chemical synthesis Heterocyclic Compounds, 2-Ring - chemistry Heterocyclic Compounds, 2-Ring - pharmacokinetics Humans Medical sciences Oncology Pharmacology. Drug treatments Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacokinetics Proto-Oncogene Proteins c-met - antagonists & inhibitors Proto-Oncogene Proteins c-met - metabolism Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacokinetics Rats Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - metabolism RON RTK inhibitors Structure-Activity Relationship Thieno[3,2- b]pyridine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!