Hypotensive activity and toxicology of constituents from root bark of Polyalthia longifolia var. pendula

A defatted extract of Polyalthia longifolia var. pendula root bark (PRB) in 50% methanol showed a significant ability to reduce blood pressure. It caused a 22% and 47% fall in mean arterial blood pressure (MABP) in rats at doses of 3 mg/kg and 30 mg/kg, respectively. Compounds purified from this ext...

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Veröffentlicht in:	Phytotherapy research 2005-10, Vol.19 (10), p.881-884
Hauptverfasser:	Saleem, Rubeena, Ahmed, Muhammad, Ahmed, Syed Iqbal, Azeem, Mohammad, Khan, Rashid Ali, Rasool, Najma, Saleem, Hina, Noor, Fatima, Faizi, Shaheen
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antihypertensive Agents - administration & dosage Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Biological and medical sciences Blood Pressure - drug effects blood pressure reducing activity Dose-Response Relationship, Drug Egg Yolk General pharmacology Hypertension - drug therapy In Vitro Techniques Male Medical sciences Mice Mice, Inbred Strains Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots Polyalthia Polyalthia longifolia var. pendula Rats Rats, Sprague-Dawley root bark
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