ON intramolecular acyl migration reaction in the development of prodrugs and the synthesis of difficult sequence-containing bioactive peptides

NOintramolecular acyl migration in Ser‐ or Thr‐containing peptides is a well‐known side reaction in peptide chemistry. It results in the mutual conversion of ester and amide bonds. Our medicinal chemistry study focused on the fact that the O‐acyl product can be readily converted to the original N‐a...

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