Involvement of serotonin receptor subtypes in the antidepressant-like effect of trim in the rat forced swimming test
Depression is a common illness with severe morbidity and mortality. Nitric oxide synthase (NOS) inhibitors are shown to elicit antidepressant-like effect in various animals models. It is widely known that serotonin plays an important role in the antidepressant-like effect of drugs. The aim of this s...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2010-05, Vol.95 (3), p.308-314 |
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| creator | Ulak, Güner Mutlu, Oguz Tanyeri, Pelin Komsuoglu, F. Ipek Akar, Füruzan Yıldız Erden, B. Faruk |
| description | Depression is a common illness with severe morbidity and mortality. Nitric oxide synthase (NOS) inhibitors are shown to elicit antidepressant-like effect in various animals models. It is widely known that serotonin plays an important role in the antidepressant-like effect of drugs. The aim of this study is to investigate the involvement of 5-HT
1 and 5-HT
2 receptor subtypes in the antidepressant-like effect of TRIM, a nNOS inhibitor, in the rat forced swimming test (FST). TRIM displays an antidepressant-like activity in FST which is blocked by pretreatment with the NOS substrate
l-arginine. Depletion of endogenous serotonin using para-chlorophenylalanine (pCPA; 3
×
150
mg/kg, i.p.) partially attenuated TRIM (50
mg/kg)-induced reductions in immobility time in FST. Pretreatment with methiothepin (0.1
mg/kg, i.p, a non-selective 5-HT receptor antagonist), cyproheptadine (3
mg/kg i.p, a 5-HT
2 receptor antagonist) or ketanserin (5
mg/kg i.p, a 5HT
2A/2C receptor antagonist) prevented the effect of TRIM (50
mg/kg) in the FST. WAY 100635 (0.1
mg/kg i.p, a selective 5-HT
1A receptor antagonist) and GR 127935 (3
mg/kg i.p, a selective 5-HT
1B/1D receptor antagonist) slightly reversed the immobility-reducing effect of TRIM in the FST, but this failed to reach a statistically significant level. The results of this study demonstrate that antidepressant-like effect of TRIM in the FST seems to be mediated, at least in part, by an interaction with 5-HT
2 receptors while non-significant effects were obtained with 5-HT
1 receptors. |
| doi_str_mv | 10.1016/j.pbb.2010.02.006 |
| format | Article |
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1 and 5-HT
2 receptor subtypes in the antidepressant-like effect of TRIM, a nNOS inhibitor, in the rat forced swimming test (FST). TRIM displays an antidepressant-like activity in FST which is blocked by pretreatment with the NOS substrate
l-arginine. Depletion of endogenous serotonin using para-chlorophenylalanine (pCPA; 3
×
150
mg/kg, i.p.) partially attenuated TRIM (50
mg/kg)-induced reductions in immobility time in FST. Pretreatment with methiothepin (0.1
mg/kg, i.p, a non-selective 5-HT receptor antagonist), cyproheptadine (3
mg/kg i.p, a 5-HT
2 receptor antagonist) or ketanserin (5
mg/kg i.p, a 5HT
2A/2C receptor antagonist) prevented the effect of TRIM (50
mg/kg) in the FST. WAY 100635 (0.1
mg/kg i.p, a selective 5-HT
1A receptor antagonist) and GR 127935 (3
mg/kg i.p, a selective 5-HT
1B/1D receptor antagonist) slightly reversed the immobility-reducing effect of TRIM in the FST, but this failed to reach a statistically significant level. The results of this study demonstrate that antidepressant-like effect of TRIM in the FST seems to be mediated, at least in part, by an interaction with 5-HT
2 receptors while non-significant effects were obtained with 5-HT
1 receptors.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/j.pbb.2010.02.006</identifier><identifier>PMID: 20171242</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>Kidlington: Elsevier Inc</publisher><subject>5-HT receptor ; Animal models ; Animals ; Antidepressant-like effect ; Antidepressive Agents - pharmacology ; Antidepressive Agents - therapeutic use ; Benzimidazoles - pharmacology ; Benzimidazoles - therapeutic use ; Biological and medical sciences ; Depression - drug therapy ; Depression - enzymology ; Depression - psychology ; Enzyme Inhibitors - pharmacology ; Enzyme Inhibitors - therapeutic use ; Forced swimming test ; Immobilization ; Isoenzymes - antagonists & inhibitors ; Isoenzymes - physiology ; Male ; Medical sciences ; Neuropharmacology ; Nitric Oxide Synthase Type I - antagonists & inhibitors ; Nitric Oxide Synthase Type I - metabolism ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Wistar ; Receptors, Serotonin - classification ; Receptors, Serotonin - physiology ; Stress, Psychological - drug therapy ; Stress, Psychological - enzymology ; Stress, Psychological - physiopathology ; Swimming ; TRIM</subject><ispartof>Pharmacology, biochemistry and behavior, 2010-05, Vol.95 (3), p.308-314</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-de78094e3e9fe868d99385e11be6163cdfa5c342bcdfd23fe6bbe5fed78652a83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pbb.2010.02.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22612322$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20171242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ulak, Güner</creatorcontrib><creatorcontrib>Mutlu, Oguz</creatorcontrib><creatorcontrib>Tanyeri, Pelin</creatorcontrib><creatorcontrib>Komsuoglu, F. Ipek</creatorcontrib><creatorcontrib>Akar, Füruzan Yıldız</creatorcontrib><creatorcontrib>Erden, B. Faruk</creatorcontrib><title>Involvement of serotonin receptor subtypes in the antidepressant-like effect of trim in the rat forced swimming test</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Depression is a common illness with severe morbidity and mortality. Nitric oxide synthase (NOS) inhibitors are shown to elicit antidepressant-like effect in various animals models. It is widely known that serotonin plays an important role in the antidepressant-like effect of drugs. The aim of this study is to investigate the involvement of 5-HT
1 and 5-HT
2 receptor subtypes in the antidepressant-like effect of TRIM, a nNOS inhibitor, in the rat forced swimming test (FST). TRIM displays an antidepressant-like activity in FST which is blocked by pretreatment with the NOS substrate
l-arginine. Depletion of endogenous serotonin using para-chlorophenylalanine (pCPA; 3
×
150
mg/kg, i.p.) partially attenuated TRIM (50
mg/kg)-induced reductions in immobility time in FST. Pretreatment with methiothepin (0.1
mg/kg, i.p, a non-selective 5-HT receptor antagonist), cyproheptadine (3
mg/kg i.p, a 5-HT
2 receptor antagonist) or ketanserin (5
mg/kg i.p, a 5HT
2A/2C receptor antagonist) prevented the effect of TRIM (50
mg/kg) in the FST. WAY 100635 (0.1
mg/kg i.p, a selective 5-HT
1A receptor antagonist) and GR 127935 (3
mg/kg i.p, a selective 5-HT
1B/1D receptor antagonist) slightly reversed the immobility-reducing effect of TRIM in the FST, but this failed to reach a statistically significant level. The results of this study demonstrate that antidepressant-like effect of TRIM in the FST seems to be mediated, at least in part, by an interaction with 5-HT
2 receptors while non-significant effects were obtained with 5-HT
1 receptors.</description><subject>5-HT receptor</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antidepressant-like effect</subject><subject>Antidepressive Agents - pharmacology</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Benzimidazoles - pharmacology</subject><subject>Benzimidazoles - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Depression - drug therapy</subject><subject>Depression - enzymology</subject><subject>Depression - psychology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Enzyme Inhibitors - therapeutic use</subject><subject>Forced swimming test</subject><subject>Immobilization</subject><subject>Isoenzymes - antagonists & inhibitors</subject><subject>Isoenzymes - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Nitric Oxide Synthase Type I - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase Type I - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Serotonin - classification</subject><subject>Receptors, Serotonin - physiology</subject><subject>Stress, Psychological - drug therapy</subject><subject>Stress, Psychological - enzymology</subject><subject>Stress, Psychological - physiopathology</subject><subject>Swimming</subject><subject>TRIM</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9vFSEUxYnR2NfWD-DGsDGu5smfGZiJK9OobdLEjV0TBi7KcwZG4D3Tb1_G96o7GxZcyO-eC-cg9JqSLSVUvN9tl3HcMlLPhG0JEc_QhvaSNx2V8jnaEDLQhpNOnqHznHeEkJYJ-RKd1RZJWcs2qNyEQ5wOMEMoODqcIcUSgw84gYGlxITzfiz3C2RcL8sPwDoUb2FJkHMtm8n_BAzOgfkjUJKfH8mkC3YxGbA4__bz7MN3XCCXS_TC6SnDq9N-ge4-f_p2dd3cfv1yc_XxtjEtbUtjQfZkaIHD4KAXvR0G3ndA6QiCCm6s053hLRtrZRl3IMYROgdW9qJjuucX6N1Rd0nx174OVrPPBqZJB4j7rGTbyepRS54mOe_XtZL0SJoUc07g1FJ_rNO9okStqaidqqmoNRVFmKqp1J43J_X9OIP92_EYQwXengCdjZ5c0sH4_I9jgjLOVu7DkYPq2sFDUtl4CNVgX-Mqykb_n2c8AN9frEc</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Ulak, Güner</creator><creator>Mutlu, Oguz</creator><creator>Tanyeri, Pelin</creator><creator>Komsuoglu, F. Ipek</creator><creator>Akar, Füruzan Yıldız</creator><creator>Erden, B. Faruk</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20100501</creationdate><title>Involvement of serotonin receptor subtypes in the antidepressant-like effect of trim in the rat forced swimming test</title><author>Ulak, Güner ; Mutlu, Oguz ; Tanyeri, Pelin ; Komsuoglu, F. Ipek ; Akar, Füruzan Yıldız ; Erden, B. Faruk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-de78094e3e9fe868d99385e11be6163cdfa5c342bcdfd23fe6bbe5fed78652a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>5-HT receptor</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antidepressant-like effect</topic><topic>Antidepressive Agents - pharmacology</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Benzimidazoles - pharmacology</topic><topic>Benzimidazoles - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Depression - drug therapy</topic><topic>Depression - enzymology</topic><topic>Depression - psychology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Enzyme Inhibitors - therapeutic use</topic><topic>Forced swimming test</topic><topic>Immobilization</topic><topic>Isoenzymes - antagonists & inhibitors</topic><topic>Isoenzymes - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Nitric Oxide Synthase Type I - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase Type I - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Serotonin - classification</topic><topic>Receptors, Serotonin - physiology</topic><topic>Stress, Psychological - drug therapy</topic><topic>Stress, Psychological - enzymology</topic><topic>Stress, Psychological - physiopathology</topic><topic>Swimming</topic><topic>TRIM</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ulak, Güner</creatorcontrib><creatorcontrib>Mutlu, Oguz</creatorcontrib><creatorcontrib>Tanyeri, Pelin</creatorcontrib><creatorcontrib>Komsuoglu, F. 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Faruk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of serotonin receptor subtypes in the antidepressant-like effect of trim in the rat forced swimming test</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>95</volume><issue>3</issue><spage>308</spage><epage>314</epage><pages>308-314</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Depression is a common illness with severe morbidity and mortality. Nitric oxide synthase (NOS) inhibitors are shown to elicit antidepressant-like effect in various animals models. It is widely known that serotonin plays an important role in the antidepressant-like effect of drugs. The aim of this study is to investigate the involvement of 5-HT
1 and 5-HT
2 receptor subtypes in the antidepressant-like effect of TRIM, a nNOS inhibitor, in the rat forced swimming test (FST). TRIM displays an antidepressant-like activity in FST which is blocked by pretreatment with the NOS substrate
l-arginine. Depletion of endogenous serotonin using para-chlorophenylalanine (pCPA; 3
×
150
mg/kg, i.p.) partially attenuated TRIM (50
mg/kg)-induced reductions in immobility time in FST. Pretreatment with methiothepin (0.1
mg/kg, i.p, a non-selective 5-HT receptor antagonist), cyproheptadine (3
mg/kg i.p, a 5-HT
2 receptor antagonist) or ketanserin (5
mg/kg i.p, a 5HT
2A/2C receptor antagonist) prevented the effect of TRIM (50
mg/kg) in the FST. WAY 100635 (0.1
mg/kg i.p, a selective 5-HT
1A receptor antagonist) and GR 127935 (3
mg/kg i.p, a selective 5-HT
1B/1D receptor antagonist) slightly reversed the immobility-reducing effect of TRIM in the FST, but this failed to reach a statistically significant level. The results of this study demonstrate that antidepressant-like effect of TRIM in the FST seems to be mediated, at least in part, by an interaction with 5-HT
2 receptors while non-significant effects were obtained with 5-HT
1 receptors.</abstract><cop>Kidlington</cop><pub>Elsevier Inc</pub><pmid>20171242</pmid><doi>10.1016/j.pbb.2010.02.006</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pharmacology, biochemistry and behavior, 2010-05, Vol.95 (3), p.308-314 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 5-HT receptor Animal models Animals Antidepressant-like effect Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Benzimidazoles - pharmacology Benzimidazoles - therapeutic use Biological and medical sciences Depression - drug therapy Depression - enzymology Depression - psychology Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Forced swimming test Immobilization Isoenzymes - antagonists & inhibitors Isoenzymes - physiology Male Medical sciences Neuropharmacology Nitric Oxide Synthase Type I - antagonists & inhibitors Nitric Oxide Synthase Type I - metabolism Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Receptors, Serotonin - classification Receptors, Serotonin - physiology Stress, Psychological - drug therapy Stress, Psychological - enzymology Stress, Psychological - physiopathology Swimming TRIM |
| title | Involvement of serotonin receptor subtypes in the antidepressant-like effect of trim in the rat forced swimming test |
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