Potential testicular toxicity of sodium nitrate in adult rats

Nitrate is a common contaminant in groundwater aquifers. Current study aimed at evaluating the potential testicular toxicity of sodium nitrate in rats. Sodium nitrate was given orally to rats at doses of 50, 100 or 200 mg/kg/day for 60 consecutive days. Sperm count and motility, daily sperm producti...

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Veröffentlicht in:	Food and chemical toxicology 2010-02, Vol.48 (2), p.572-578
Hauptverfasser:	Aly, Hamdy A.A., Mansour, Ahmed M., Abo-Salem, Osama M., Abd-Ellah, Hala F., Abdel-Naim, Ashraf B.
Format:	Artikel
Sprache:	eng
Schlagworte:	acid phosphatase Administration, Oral animal models Animals aquifers Biological and medical sciences Catalase Cell Death - drug effects Cell Death - physiology Counting Enzyme Inhibitors - toxicity Enzymes Enzymes - metabolism glucose-6-phosphate 1-dehydrogenase Glutathione Glutathione - metabolism glutathione peroxidase glutathione reductase (NADPH) hydrogen peroxide Hydrogen Peroxide - metabolism lipid peroxidation Lipid Peroxidation - drug effects Male Medical sciences Nitrates - toxicity Organ Size - drug effects Oxidative stress Oxidative Stress - drug effects Oxidoreductases - metabolism Rats Reductases Sodium nitrate Sodium nitrates Sperm Count sperm motility Sperm Motility - drug effects Spermatocytes - drug effects Spermatocytes - pathology Spermatogenesis Spermatozoa - drug effects Spermatozoa - pathology superoxide dismutase testes Testis Testis - drug effects Testis - enzymology Testis - pathology Toxicity Toxicology Water Pollutants, Chemical - toxicity water pollution water supply
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