Development and Characterization of a Novel Human In Vitro Blood-Nerve Barrier Model Using Primary Endoneurial Endothelial Cells

There are phenotypic and functional differences between vascular endothelium from different tissues and between microvascular and macrovascular endothelial cells (ECs) from the same tissue. Relatively little is known about the human blood-nerve barrier (BNB). We report the development of an in vitro...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2010-01, Vol.69 (1), p.82-97
Hauptverfasser:	Yosef, Nejla, Xia, Robin H, Ubogu, Eroboghene E
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism ATP-Binding Cassette, Sub-Family B, Member 1 Biological and medical sciences Biological Transport - physiology Biophysical Phenomena - physiology Blood-Brain Barrier - physiology Blood-Brain Barrier - ultrastructure Blood-Nerve Barrier - cytology Cell Adhesion Molecules - metabolism Cell Differentiation Cells, Cultured Dextrans - metabolism Electric Impedance Electric Stimulation - methods Endothelial Cells - physiology Endothelial Cells - ultrastructure Flow Cytometry gamma-Glutamyltransferase - metabolism Humans In Vitro Techniques Lipoproteins, LDL - metabolism Medical sciences Membrane Proteins - metabolism Membrane Transport Proteins - metabolism Microscopy, Electron, Transmission Models, Biological Neovascularization, Physiologic - physiology Neurology Peripheral Nerves - cytology Plant Lectins - metabolism Sciatic Nerve - cytology Tight Junctions - metabolism Tight Junctions - ultrastructure Tumors of the nervous system. Phacomatoses Ulex europaeus von Willebrand Factor - metabolism
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