Magnetic Resonance Imaging of Alzheimer's Pathology in the Brains of Living Transgenic Mice: A New Tool in Alzheimer's Disease Research

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Cardinal pathologic features of AD are amyloid plaques and neurofibrillary tangles, and most in the field believe that the initiating events ultimately leading to clinical AD center on disordered metabolism of amyloid...

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Veröffentlicht in:	The Neuroscientist (Baltimore, Md.) Md.), 2007-02, Vol.13 (1), p.38-48
Hauptverfasser:	Jack, Clifford R., Marjanska, Malgorzata, Wengenack, Thomas M., Reyes, Denise A., Curran, Geoffrey L., Lin, Joseph, Preboske, Gregory M., Poduslo, Joseph F., Garwood, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Animals Brain - metabolism Brain - pathology Brain - physiopathology Development and progression Disease Models, Animal Health aspects Humans Magnetic resonance imaging Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy - methods Mice Mice, Transgenic Physiological aspects Plaque, Amyloid - genetics Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Radioisotopes
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