Evaluation needle length and density of microneedle arrays in the pretreatment of skin for transdermal drug delivery

Solid silicon microneedle arrays with different needle lengths (ranging from 100 to 1100 μm) and needle densities (ranging from 400 to 11,900 needles/cm 2) were used to penetrate epidermal membrane of human cadaver skin. After this pretreatment, the electrical resistance of the skin and the flux of...

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Veröffentlicht in:	International journal of pharmaceutics 2010-05, Vol.391 (1), p.7-12
Hauptverfasser:	Yan, Guang, Warner, Kevin S., Zhang, Jie, Sharma, Sanjay, Gale, Bruce K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - pharmacokinetics Administration, Cutaneous Animals Biological and medical sciences Drug delivery Drug Delivery Systems - instrumentation Electric Impedance Epidermis - metabolism Female General pharmacology Humans In Vitro Techniques Medical sciences Microneedles Needle density Needle length Needles Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Rats, Hairless Skin Absorption - physiology Technology, Pharmaceutical - methods Transdermal Water Loss, Insensible
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