Antinociceptive effect of three common analgesic drugs on peripheral neuropathy induced by paclitaxel in rats

Nowadays, there are no validated drugs to control the neuropathic pain induced by paclitaxel, one of the most effective antineoplastic drugs. The aim was to study the involvement of opioid and NMDA receptor on established paclitaxel-induced pain, testing three common analgesics drugs morphine, ketam...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2010-05, Vol.95 (3), p.331-337
Hauptverfasser:	Pascual, David, Goicoechea, Carlos, Burgos, Elisa, Martín, María Isabel
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics - therapeutic use Animal models Animals Biological and medical sciences Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Male Medical sciences Nervous system (semeiology, syndromes) Neurology Neuropathic pain NMDA receptors Opioids Paclitaxel Paclitaxel - toxicity Pain Measurement - drug effects Pain Measurement - methods Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - drug therapy Rats Rats, Wistar
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