Age-related association of fine particles and ozone with severe acute asthma in New York City
Background Ambient fine particles (particular matter
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2010-02, Vol.125 (2), p.367-373.e5 |
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| container_end_page | 373.e5 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Silverman, Robert A., MD Ito, Kazuhiko, PhD |
| description | Background Ambient fine particles (particular matter |
| doi_str_mv | 10.1016/j.jaci.2009.10.061 |
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There is little documentation determining whether children are more vulnerable to the effects of ambient pollution than adults, or whether pollution causes life-threatening episodes requiring intensive care unit (ICU) admission. Objective We investigate the relationship between severe asthma morbidity and PM2.5 and ozone in the warm season, and determine whether there is an age-related susceptibility to pollution. Methods Daily time-series analysis of 6008 asthma ICU admissions and 69,375 general (non-ICU) asthma admissions in 4 age groups (<6, 6-18, 19-49, and 50+ years) in 74 New York City hospitals for the months April to August from 1999 to 2006. The regression model adjusted for temporal trends, weather, and day of the week. Risks were estimated for interquartile range increases in the a priori exposure time window of the average of 0-day and 1-day lagged pollutants. Results Age was a significant effect modifier for hospitalizations, and children age 6 to 18 years consistently had the highest risk. Among children age 6 to 18 years, there was a 26% (95% CI, 10% to 44%) increased rate of ICU admissions and a 19% increased rate of general hospitalizations (95% CI, 12% to 27%) for each 12-μg/m3 increase in PM2.5 . For each 22-ppb increase in ozone, there was a 19% (95% CI, 1% to 40%) increased risk for ICU admissions and a 20% (95% CI, 11% to 29%) increased risk for general hospitalizations. Conclusion Warm weather patterns of ozone and PM2.5 disproportionately affect children with asthma and appear responsible for severe attacks that could have been avoided.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2009.10.061</identifier><identifier>PMID: 20159246</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Age ; Age Factors ; Aged ; Air Pollutants - adverse effects ; Air pollution ; Air Pollution - adverse effects ; Allergy and Immunology ; Asthma - etiology ; Atmospheric pressure ; Atoms & subatomic particles ; Biological and medical sciences ; Child ; Child, Preschool ; Chronic obstructive pulmonary disease, asthma ; Coal-fired power plants ; emergency ; Estimates ; exacerbation ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Generalized linear models ; Hospitalization ; Humans ; Humidity ; Immunopathology ; Intensive care ; intensive care unit ; Medical sciences ; Middle Aged ; Morbidity ; Mortality ; New York City ; ozone ; Ozone - adverse effects ; Particulate Matter - adverse effects ; Patient Admission - statistics & numerical data ; PM 2.5, asthma ; Pneumology ; Pollutants ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Seasons ; Sensitivity analysis ; Temperature effects ; Variables ; Young Adult</subject><ispartof>Journal of allergy and clinical immunology, 2010-02, Vol.125 (2), p.367-373.e5</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2010 American Academy of Allergy, Asthma & Immunology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-75b30ffeb7a743a440559636637d55f5bb4c317e83eea8edb5c0aaaa5c3a2e4b3</citedby><cites>FETCH-LOGICAL-c500t-75b30ffeb7a743a440559636637d55f5bb4c317e83eea8edb5c0aaaa5c3a2e4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2009.10.061$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22406082$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20159246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silverman, Robert A., MD</creatorcontrib><creatorcontrib>Ito, Kazuhiko, PhD</creatorcontrib><title>Age-related association of fine particles and ozone with severe acute asthma in New York City</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background Ambient fine particles (particular matter <2.5 μm diameter [PM2.5 ]) and ozone exacerbate respiratory conditions including asthma. There is little documentation determining whether children are more vulnerable to the effects of ambient pollution than adults, or whether pollution causes life-threatening episodes requiring intensive care unit (ICU) admission. Objective We investigate the relationship between severe asthma morbidity and PM2.5 and ozone in the warm season, and determine whether there is an age-related susceptibility to pollution. Methods Daily time-series analysis of 6008 asthma ICU admissions and 69,375 general (non-ICU) asthma admissions in 4 age groups (<6, 6-18, 19-49, and 50+ years) in 74 New York City hospitals for the months April to August from 1999 to 2006. The regression model adjusted for temporal trends, weather, and day of the week. Risks were estimated for interquartile range increases in the a priori exposure time window of the average of 0-day and 1-day lagged pollutants. Results Age was a significant effect modifier for hospitalizations, and children age 6 to 18 years consistently had the highest risk. Among children age 6 to 18 years, there was a 26% (95% CI, 10% to 44%) increased rate of ICU admissions and a 19% increased rate of general hospitalizations (95% CI, 12% to 27%) for each 12-μg/m3 increase in PM2.5 . For each 22-ppb increase in ozone, there was a 19% (95% CI, 1% to 40%) increased risk for ICU admissions and a 20% (95% CI, 11% to 29%) increased risk for general hospitalizations. Conclusion Warm weather patterns of ozone and PM2.5 disproportionately affect children with asthma and appear responsible for severe attacks that could have been avoided.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Air Pollutants - adverse effects</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Allergy and Immunology</subject><subject>Asthma - etiology</subject><subject>Atmospheric pressure</subject><subject>Atoms & subatomic particles</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Coal-fired power plants</subject><subject>emergency</subject><subject>Estimates</subject><subject>exacerbation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Generalized linear models</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Humidity</subject><subject>Immunopathology</subject><subject>Intensive care</subject><subject>intensive care unit</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>New York City</subject><subject>ozone</subject><subject>Ozone - adverse effects</subject><subject>Particulate Matter - adverse effects</subject><subject>Patient Admission - statistics & numerical data</subject><subject>PM 2.5, asthma</subject><subject>Pneumology</subject><subject>Pollutants</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Seasons</subject><subject>Sensitivity analysis</subject><subject>Temperature effects</subject><subject>Variables</subject><subject>Young Adult</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2LFDEQhoMo7rj6BzxIQMRTj_lON4iwDH7BogcV9CAhna5209vTGZP0LuOvN82MLuxBc0ioylNVqbyF0GNK1pRQ9WJYD9b5NSOkKY41UfQOWlHS6ErVTN5Fq3JBK6VFc4IepDSQYvO6uY9OGKGyYUKt0PezH1BFGG2GDtuUgvM2-zDh0OPeT4B3NmbvRkjYTh0Ov0LxXft8gRNcQQRs3ZzLnvLF1mI_4Q9wjb-FeIk3Pu8fonu9HRM8Op6n6Mub158376rzj2_fb87OKycJyZWWLSd9D622WnArBJGyUVwprjspe9m2wnGqoeYAtoaulY7YsqTjloFo-Sl6fsi7i-HnDCmbrU8OxtFOEOZktJCq0bqR_yc5ryVvBCnk01vkEOY4lTYMlUTUtGacFYodKBdDShF6s4t-a-PeUGIWlcxgFpXMotLiKyqVoCfH1HO7he5vyB9ZCvDsCNjk7NhHOzmfbjgmiCL1Uv3lgYPyuVceoknOw-Sg8xFcNl3w_37Hq1vhbvSTLxUvYQ_ppl-TmCHm0zJPyziRpiQU7Cv_DY7Rw_0</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Silverman, Robert A., MD</creator><creator>Ito, Kazuhiko, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20100201</creationdate><title>Age-related association of fine particles and ozone with severe acute asthma in New York City</title><author>Silverman, Robert A., MD ; Ito, Kazuhiko, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-75b30ffeb7a743a440559636637d55f5bb4c317e83eea8edb5c0aaaa5c3a2e4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Air Pollutants - adverse effects</topic><topic>Air pollution</topic><topic>Air Pollution - adverse effects</topic><topic>Allergy and Immunology</topic><topic>Asthma - etiology</topic><topic>Atmospheric pressure</topic><topic>Atoms & subatomic particles</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Coal-fired power plants</topic><topic>emergency</topic><topic>Estimates</topic><topic>exacerbation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Generalized linear models</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Humidity</topic><topic>Immunopathology</topic><topic>Intensive care</topic><topic>intensive care unit</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>New York City</topic><topic>ozone</topic><topic>Ozone - adverse effects</topic><topic>Particulate Matter - adverse effects</topic><topic>Patient Admission - statistics & numerical data</topic><topic>PM 2.5, asthma</topic><topic>Pneumology</topic><topic>Pollutants</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Seasons</topic><topic>Sensitivity analysis</topic><topic>Temperature effects</topic><topic>Variables</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silverman, Robert A., MD</creatorcontrib><creatorcontrib>Ito, Kazuhiko, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silverman, Robert A., MD</au><au>Ito, Kazuhiko, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related association of fine particles and ozone with severe acute asthma in New York City</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>125</volume><issue>2</issue><spage>367</spage><epage>373.e5</epage><pages>367-373.e5</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Background Ambient fine particles (particular matter <2.5 μm diameter [PM2.5 ]) and ozone exacerbate respiratory conditions including asthma. There is little documentation determining whether children are more vulnerable to the effects of ambient pollution than adults, or whether pollution causes life-threatening episodes requiring intensive care unit (ICU) admission. Objective We investigate the relationship between severe asthma morbidity and PM2.5 and ozone in the warm season, and determine whether there is an age-related susceptibility to pollution. Methods Daily time-series analysis of 6008 asthma ICU admissions and 69,375 general (non-ICU) asthma admissions in 4 age groups (<6, 6-18, 19-49, and 50+ years) in 74 New York City hospitals for the months April to August from 1999 to 2006. The regression model adjusted for temporal trends, weather, and day of the week. Risks were estimated for interquartile range increases in the a priori exposure time window of the average of 0-day and 1-day lagged pollutants. Results Age was a significant effect modifier for hospitalizations, and children age 6 to 18 years consistently had the highest risk. Among children age 6 to 18 years, there was a 26% (95% CI, 10% to 44%) increased rate of ICU admissions and a 19% increased rate of general hospitalizations (95% CI, 12% to 27%) for each 12-μg/m3 increase in PM2.5 . For each 22-ppb increase in ozone, there was a 19% (95% CI, 1% to 40%) increased risk for ICU admissions and a 20% (95% CI, 11% to 29%) increased risk for general hospitalizations. Conclusion Warm weather patterns of ozone and PM2.5 disproportionately affect children with asthma and appear responsible for severe attacks that could have been avoided.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>20159246</pmid><doi>10.1016/j.jaci.2009.10.061</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Age Age Factors Aged Air Pollutants - adverse effects Air pollution Air Pollution - adverse effects Allergy and Immunology Asthma - etiology Atmospheric pressure Atoms & subatomic particles Biological and medical sciences Child Child, Preschool Chronic obstructive pulmonary disease, asthma Coal-fired power plants emergency Estimates exacerbation Fundamental and applied biological sciences. Psychology Fundamental immunology Generalized linear models Hospitalization Humans Humidity Immunopathology Intensive care intensive care unit Medical sciences Middle Aged Morbidity Mortality New York City ozone Ozone - adverse effects Particulate Matter - adverse effects Patient Admission - statistics & numerical data PM 2.5, asthma Pneumology Pollutants Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Seasons Sensitivity analysis Temperature effects Variables Young Adult |
| title | Age-related association of fine particles and ozone with severe acute asthma in New York City |
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