Translocation of Lysosomal Cathepsin D Caused by Oxidative Stress or Proteasome Inhibition in Primary Cultured Neurons and Astrocytes

We reported previously that N-linked glycoproteins were accumulated in the cytosol of the normal aging rat brain, and that one protein had been identified as cathepsin D (Mech. Ageing Dev., 127, 771—778 (2006)). In this study, to elucidate the mechanism of cathepsin D accumulation in the cytosol, we...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2010/01/01, Vol.33(1), pp.22-28
Hauptverfasser:	Miura, Yuri, Sakurai, Yoko, Hayakawa, Masato, Shimada, Yukiko, Zempel, Hans, Sato, Yuji, Hisanaga, Shin-ichi, Endo, Tamao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - analogs & derivatives Aging - physiology Animals Apoptosis - physiology Astrocytes - metabolism Biological Transport cathepsin D Cathepsin D - metabolism Cells, Cultured Cytosol - metabolism Lysosomes - metabolism N-linked glycoprotein Neurons - metabolism oxidative stress Oxidative Stress - physiology proteasome inhibition Proteasome Inhibitors Rats Rats, Wistar tert-Butylhydroperoxide
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