The added value of multislice SPECT/CT in patients with equivocal bony metastasis from carcinoma of the prostate
Purpose The purpose of this study was to investigate the additional value of single photon emission computed tomography/computed tomography (SPECT/CT) over whole-body planar bone scintigraphy and SPECT in prostate cancer patients in terms of diagnostic confidence, inter-reviewer agreement and the po...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2010-04, Vol.37 (4), p.706-713 |
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| creator | Helyar, Vincent Mohan, Hosahalli K. Barwick, Tara Livieratos, Lefteris Gnanasegaran, Gopinath Clarke, Susan E. M. Fogelman, Ignac |
| description | Purpose
The purpose of this study was to investigate the additional value of single photon emission computed tomography/computed tomography (SPECT/CT) over whole-body planar bone scintigraphy and SPECT in prostate cancer patients in terms of diagnostic confidence, inter-reviewer agreement and the possible impact on the clinical management.
Methods
This was a retrospective review of 40 consecutive prostate cancer patients (mean age 71 years) who underwent
99m
Tc-methylene diphosphonate (MDP) whole-body planar bone scintigraphy, SPECT and SPECT/CT between April 2006 and April 2008. The images were evaluated by two independent reviewers; inter-reviewer agreement was evaluated using a weighted kappa score. Each focus of abnormal increased tracer uptake was recorded using a 4-point diagnostic confidence scale. Institutional Review Board approval was obtained.
Results
Fifty lesions on planar bone scintigraphy in the 40 patients were evaluated. On reporting the planar study and SPECT scans, reviewers rated 61% of lesions as equivocal. On reporting the SPECT/CT scans only 8% of lesions were rated as equivocal, 24% were rated as malignant and 68% as benign. Weighted kappa scores for inter-reviewer agreement were 0.43 for bone scintigraphy, 0.56 for SPECT and 0.87 for SPECT/CT. All were significant at
p
|
| doi_str_mv | 10.1007/s00259-009-1334-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_745696678</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1995092741</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-113fbb078ffe0c9b39a7bc2f6c585f11329ca5cd0c53413c101f4045c9524d2e3</originalsourceid><addsrcrecordid>eNqFkVtLHTEUhUNRqrX9AX0pwRefpu7cZpLHcvBSEBQ8fQ6ZzE6NzOU4ySj-e3M41oJQCoFsWN9ei80i5CuD7wygOU0AXJkKwFRMCFmJD-SQ1cxUDWiz9zY3cEA-pXQPwDTX5iM54GWstTaHZLO-Q-q6Djv66PoF6RTosPQ5pj56pLc3Z6v16WpN40g3Lkccc6JPMd9RfFji4-RdT9tpfKYDZpfKi4mGeRqod7OP4zS4rWEuGZt5KnrGz2Q_uD7hl9f_iPw6P1uvLqur64ufqx9XlZfAc8WYCG0LjQ4BwZtWGNe0nofaK61CUbnxTvkOvBKSCc-ABQlSeaO47DiKI3Ky8y3BDwumbIeYPPa9G3Fakm2kqk1dN_r_pBCiNqyRhTx-R95PyzyWMyxnspZaSFUgtoN8uTjNGOxmjoObny0Du63N7mqzpTa7rc2KsvPt1XhpB-zeNv70VAC-A1KRxt84_03-t-sLAAuh-g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214648345</pqid></control><display><type>article</type><title>The added value of multislice SPECT/CT in patients with equivocal bony metastasis from carcinoma of the prostate</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Helyar, Vincent ; Mohan, Hosahalli K. ; Barwick, Tara ; Livieratos, Lefteris ; Gnanasegaran, Gopinath ; Clarke, Susan E. M. ; Fogelman, Ignac</creator><creatorcontrib>Helyar, Vincent ; Mohan, Hosahalli K. ; Barwick, Tara ; Livieratos, Lefteris ; Gnanasegaran, Gopinath ; Clarke, Susan E. M. ; Fogelman, Ignac</creatorcontrib><description>Purpose
The purpose of this study was to investigate the additional value of single photon emission computed tomography/computed tomography (SPECT/CT) over whole-body planar bone scintigraphy and SPECT in prostate cancer patients in terms of diagnostic confidence, inter-reviewer agreement and the possible impact on the clinical management.
Methods
This was a retrospective review of 40 consecutive prostate cancer patients (mean age 71 years) who underwent
99m
Tc-methylene diphosphonate (MDP) whole-body planar bone scintigraphy, SPECT and SPECT/CT between April 2006 and April 2008. The images were evaluated by two independent reviewers; inter-reviewer agreement was evaluated using a weighted kappa score. Each focus of abnormal increased tracer uptake was recorded using a 4-point diagnostic confidence scale. Institutional Review Board approval was obtained.
Results
Fifty lesions on planar bone scintigraphy in the 40 patients were evaluated. On reporting the planar study and SPECT scans, reviewers rated 61% of lesions as equivocal. On reporting the SPECT/CT scans only 8% of lesions were rated as equivocal, 24% were rated as malignant and 68% as benign. Weighted kappa scores for inter-reviewer agreement were 0.43 for bone scintigraphy, 0.56 for SPECT and 0.87 for SPECT/CT. All were significant at
p
< 0.0001. Follow-up imaging confirmed the SPECT/CT diagnoses in 14 patients.
Conclusion
The addition of SPECT/CT resulted in a significant reduction of equivocal reports; a definitive diagnosis was given in the majority of the patients due to the improved diagnostic confidence compared to planar or SPECT imaging alone in prostate cancer patients with suspected bone metastases.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-009-1334-3</identifier><identifier>PMID: 20016889</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - secondary ; Aged ; Aged, 80 and over ; Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - secondary ; Bones ; Cardiology ; Cell division ; Diagnosis, Differential ; Fractures, Compression - diagnosis ; Humans ; Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nuclear Medicine ; Observer Variation ; Oncology ; Original Article ; Orthopedics ; Patient Care Planning ; Patients ; Prostate cancer ; Prostatic Neoplasms - pathology ; Radiology ; Retrospective Studies ; Spinal Fractures - diagnosis ; Spinal Neoplasms - diagnostic imaging ; Spinal Neoplasms - secondary ; Tomography, Emission-Computed, Single-Photon ; Tomography, Spiral Computed ; Whole Body Imaging</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2010-04, Vol.37 (4), p.706-713</ispartof><rights>Springer-Verlag 2009</rights><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-113fbb078ffe0c9b39a7bc2f6c585f11329ca5cd0c53413c101f4045c9524d2e3</citedby><cites>FETCH-LOGICAL-c402t-113fbb078ffe0c9b39a7bc2f6c585f11329ca5cd0c53413c101f4045c9524d2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-009-1334-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-009-1334-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20016889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Helyar, Vincent</creatorcontrib><creatorcontrib>Mohan, Hosahalli K.</creatorcontrib><creatorcontrib>Barwick, Tara</creatorcontrib><creatorcontrib>Livieratos, Lefteris</creatorcontrib><creatorcontrib>Gnanasegaran, Gopinath</creatorcontrib><creatorcontrib>Clarke, Susan E. M.</creatorcontrib><creatorcontrib>Fogelman, Ignac</creatorcontrib><title>The added value of multislice SPECT/CT in patients with equivocal bony metastasis from carcinoma of the prostate</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
The purpose of this study was to investigate the additional value of single photon emission computed tomography/computed tomography (SPECT/CT) over whole-body planar bone scintigraphy and SPECT in prostate cancer patients in terms of diagnostic confidence, inter-reviewer agreement and the possible impact on the clinical management.
Methods
This was a retrospective review of 40 consecutive prostate cancer patients (mean age 71 years) who underwent
99m
Tc-methylene diphosphonate (MDP) whole-body planar bone scintigraphy, SPECT and SPECT/CT between April 2006 and April 2008. The images were evaluated by two independent reviewers; inter-reviewer agreement was evaluated using a weighted kappa score. Each focus of abnormal increased tracer uptake was recorded using a 4-point diagnostic confidence scale. Institutional Review Board approval was obtained.
Results
Fifty lesions on planar bone scintigraphy in the 40 patients were evaluated. On reporting the planar study and SPECT scans, reviewers rated 61% of lesions as equivocal. On reporting the SPECT/CT scans only 8% of lesions were rated as equivocal, 24% were rated as malignant and 68% as benign. Weighted kappa scores for inter-reviewer agreement were 0.43 for bone scintigraphy, 0.56 for SPECT and 0.87 for SPECT/CT. All were significant at
p
< 0.0001. Follow-up imaging confirmed the SPECT/CT diagnoses in 14 patients.
Conclusion
The addition of SPECT/CT resulted in a significant reduction of equivocal reports; a definitive diagnosis was given in the majority of the patients due to the improved diagnostic confidence compared to planar or SPECT imaging alone in prostate cancer patients with suspected bone metastases.</description><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - secondary</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - secondary</subject><subject>Bones</subject><subject>Cardiology</subject><subject>Cell division</subject><subject>Diagnosis, Differential</subject><subject>Fractures, Compression - diagnosis</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nuclear Medicine</subject><subject>Observer Variation</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Patient Care Planning</subject><subject>Patients</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Spinal Fractures - diagnosis</subject><subject>Spinal Neoplasms - diagnostic imaging</subject><subject>Spinal Neoplasms - secondary</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Tomography, Spiral Computed</subject><subject>Whole Body Imaging</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkVtLHTEUhUNRqrX9AX0pwRefpu7cZpLHcvBSEBQ8fQ6ZzE6NzOU4ySj-e3M41oJQCoFsWN9ei80i5CuD7wygOU0AXJkKwFRMCFmJD-SQ1cxUDWiz9zY3cEA-pXQPwDTX5iM54GWstTaHZLO-Q-q6Djv66PoF6RTosPQ5pj56pLc3Z6v16WpN40g3Lkccc6JPMd9RfFji4-RdT9tpfKYDZpfKi4mGeRqod7OP4zS4rWEuGZt5KnrGz2Q_uD7hl9f_iPw6P1uvLqur64ufqx9XlZfAc8WYCG0LjQ4BwZtWGNe0nofaK61CUbnxTvkOvBKSCc-ABQlSeaO47DiKI3Ky8y3BDwumbIeYPPa9G3Fakm2kqk1dN_r_pBCiNqyRhTx-R95PyzyWMyxnspZaSFUgtoN8uTjNGOxmjoObny0Du63N7mqzpTa7rc2KsvPt1XhpB-zeNv70VAC-A1KRxt84_03-t-sLAAuh-g</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Helyar, Vincent</creator><creator>Mohan, Hosahalli K.</creator><creator>Barwick, Tara</creator><creator>Livieratos, Lefteris</creator><creator>Gnanasegaran, Gopinath</creator><creator>Clarke, Susan E. M.</creator><creator>Fogelman, Ignac</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20100401</creationdate><title>The added value of multislice SPECT/CT in patients with equivocal bony metastasis from carcinoma of the prostate</title><author>Helyar, Vincent ; Mohan, Hosahalli K. ; Barwick, Tara ; Livieratos, Lefteris ; Gnanasegaran, Gopinath ; Clarke, Susan E. M. ; Fogelman, Ignac</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-113fbb078ffe0c9b39a7bc2f6c585f11329ca5cd0c53413c101f4045c9524d2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - secondary</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - secondary</topic><topic>Bones</topic><topic>Cardiology</topic><topic>Cell division</topic><topic>Diagnosis, Differential</topic><topic>Fractures, Compression - diagnosis</topic><topic>Humans</topic><topic>Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nuclear Medicine</topic><topic>Observer Variation</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Patient Care Planning</topic><topic>Patients</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Spinal Fractures - diagnosis</topic><topic>Spinal Neoplasms - diagnostic imaging</topic><topic>Spinal Neoplasms - secondary</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Tomography, Spiral Computed</topic><topic>Whole Body Imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Helyar, Vincent</creatorcontrib><creatorcontrib>Mohan, Hosahalli K.</creatorcontrib><creatorcontrib>Barwick, Tara</creatorcontrib><creatorcontrib>Livieratos, Lefteris</creatorcontrib><creatorcontrib>Gnanasegaran, Gopinath</creatorcontrib><creatorcontrib>Clarke, Susan E. M.</creatorcontrib><creatorcontrib>Fogelman, Ignac</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Helyar, Vincent</au><au>Mohan, Hosahalli K.</au><au>Barwick, Tara</au><au>Livieratos, Lefteris</au><au>Gnanasegaran, Gopinath</au><au>Clarke, Susan E. M.</au><au>Fogelman, Ignac</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The added value of multislice SPECT/CT in patients with equivocal bony metastasis from carcinoma of the prostate</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>37</volume><issue>4</issue><spage>706</spage><epage>713</epage><pages>706-713</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
The purpose of this study was to investigate the additional value of single photon emission computed tomography/computed tomography (SPECT/CT) over whole-body planar bone scintigraphy and SPECT in prostate cancer patients in terms of diagnostic confidence, inter-reviewer agreement and the possible impact on the clinical management.
Methods
This was a retrospective review of 40 consecutive prostate cancer patients (mean age 71 years) who underwent
99m
Tc-methylene diphosphonate (MDP) whole-body planar bone scintigraphy, SPECT and SPECT/CT between April 2006 and April 2008. The images were evaluated by two independent reviewers; inter-reviewer agreement was evaluated using a weighted kappa score. Each focus of abnormal increased tracer uptake was recorded using a 4-point diagnostic confidence scale. Institutional Review Board approval was obtained.
Results
Fifty lesions on planar bone scintigraphy in the 40 patients were evaluated. On reporting the planar study and SPECT scans, reviewers rated 61% of lesions as equivocal. On reporting the SPECT/CT scans only 8% of lesions were rated as equivocal, 24% were rated as malignant and 68% as benign. Weighted kappa scores for inter-reviewer agreement were 0.43 for bone scintigraphy, 0.56 for SPECT and 0.87 for SPECT/CT. All were significant at
p
< 0.0001. Follow-up imaging confirmed the SPECT/CT diagnoses in 14 patients.
Conclusion
The addition of SPECT/CT resulted in a significant reduction of equivocal reports; a definitive diagnosis was given in the majority of the patients due to the improved diagnostic confidence compared to planar or SPECT imaging alone in prostate cancer patients with suspected bone metastases.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20016889</pmid><doi>10.1007/s00259-009-1334-3</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1619-7070 |
| ispartof | European journal of nuclear medicine and molecular imaging, 2010-04, Vol.37 (4), p.706-713 |
| issn | 1619-7070 1619-7089 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adenocarcinoma - diagnostic imaging Adenocarcinoma - secondary Aged Aged, 80 and over Bone Neoplasms - diagnostic imaging Bone Neoplasms - secondary Bones Cardiology Cell division Diagnosis, Differential Fractures, Compression - diagnosis Humans Imaging Male Medicine Medicine & Public Health Middle Aged Nuclear Medicine Observer Variation Oncology Original Article Orthopedics Patient Care Planning Patients Prostate cancer Prostatic Neoplasms - pathology Radiology Retrospective Studies Spinal Fractures - diagnosis Spinal Neoplasms - diagnostic imaging Spinal Neoplasms - secondary Tomography, Emission-Computed, Single-Photon Tomography, Spiral Computed Whole Body Imaging |
| title | The added value of multislice SPECT/CT in patients with equivocal bony metastasis from carcinoma of the prostate |
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