A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin
Apoptotic death of mouse thymocytes in vitro, as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas...
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| Veröffentlicht in: | Biotechnology letters 2005-02, Vol.27 (4), p.253-257 |
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| container_title | Biotechnology letters |
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| creator | Ji, Hee Jung Yeo, Hee Kyoung Lee, Nam Hee Hwang, Jung Suk Koo, Kyung Ah Cheong, Seon Woo Park, Joo Hung Oh, Gap Soo Yoon, Chun Sik Youn, Hyun Joo |
| description | Apoptotic death of mouse thymocytes in vitro, as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas gene expression. We have now investigated whether the AIP1 fraction modulates TCDD-induced thymocyte death. When treated with TCDD and AIP1 fraction together, the thymocytes do not show apoptosis induced by the TCDD treatment. The AIP1 supplementation to the TCDD treatment also down-regulates the TCDD-induced Fas gene up-regulation. These findings indicate that the AIP1 fraction suppresses TCDD-induced thymocyte apoptosis through the modulation of Fas gene expression. |
| doi_str_mv | 10.1007/s10529-004-8294-2 |
| format | Article |
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We have now investigated whether the AIP1 fraction modulates TCDD-induced thymocyte death. When treated with TCDD and AIP1 fraction together, the thymocytes do not show apoptosis induced by the TCDD treatment. The AIP1 supplementation to the TCDD treatment also down-regulates the TCDD-induced Fas gene up-regulation. These findings indicate that the AIP1 fraction suppresses TCDD-induced thymocyte apoptosis through the modulation of Fas gene expression.</description><identifier>ISSN: 0141-5492</identifier><identifier>EISSN: 1573-6776</identifier><identifier>DOI: 10.1007/s10529-004-8294-2</identifier><identifier>PMID: 15742146</identifier><identifier>CODEN: BILED3</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Animals ; Apoptosis ; Apoptosis - drug effects ; Apoptosis - physiology ; Artemisia - metabolism ; Artemisia iwayomogi ; Biological and medical sciences ; Biotechnology ; Carbohydrates ; Carbohydrates - pharmacology ; Cell Survival - drug effects ; Cell Survival - physiology ; Cells, Cultured ; Dioxins ; Dioxins - pharmacology ; Dose-Response Relationship, Drug ; Down-Regulation - drug effects ; Down-Regulation - physiology ; Drug Interactions ; Fas antigen ; fas Receptor ; Female ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Mice ; Mice, Inbred C57BL ; Mortality ; Q1 ; Q2 ; Receptors, Tumor Necrosis Factor - metabolism ; TCDD ; Thymocytes ; Thymus Gland - drug effects ; Thymus Gland - metabolism</subject><ispartof>Biotechnology letters, 2005-02, Vol.27 (4), p.253-257</ispartof><rights>2005 INIST-CNRS</rights><rights>Springer 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-a44bc02a3a5530bdb1b603cfead1247a8a31ff264903209e617666bf463611753</citedby><cites>FETCH-LOGICAL-c454t-a44bc02a3a5530bdb1b603cfead1247a8a31ff264903209e617666bf463611753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16627847$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15742146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ji, Hee Jung</creatorcontrib><creatorcontrib>Yeo, Hee Kyoung</creatorcontrib><creatorcontrib>Lee, Nam Hee</creatorcontrib><creatorcontrib>Hwang, Jung Suk</creatorcontrib><creatorcontrib>Koo, Kyung Ah</creatorcontrib><creatorcontrib>Cheong, Seon Woo</creatorcontrib><creatorcontrib>Park, Joo Hung</creatorcontrib><creatorcontrib>Oh, Gap Soo</creatorcontrib><creatorcontrib>Yoon, Chun Sik</creatorcontrib><creatorcontrib>Youn, Hyun Joo</creatorcontrib><title>A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin</title><title>Biotechnology letters</title><addtitle>Biotechnol Lett</addtitle><description>Apoptotic death of mouse thymocytes in vitro, as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas gene expression. We have now investigated whether the AIP1 fraction modulates TCDD-induced thymocyte death. When treated with TCDD and AIP1 fraction together, the thymocytes do not show apoptosis induced by the TCDD treatment. The AIP1 supplementation to the TCDD treatment also down-regulates the TCDD-induced Fas gene up-regulation. These findings indicate that the AIP1 fraction suppresses TCDD-induced thymocyte apoptosis through the modulation of Fas gene expression.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - physiology</subject><subject>Artemisia - metabolism</subject><subject>Artemisia iwayomogi</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Carbohydrates</subject><subject>Carbohydrates - pharmacology</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - physiology</subject><subject>Cells, Cultured</subject><subject>Dioxins</subject><subject>Dioxins - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Down-Regulation - drug effects</subject><subject>Down-Regulation - physiology</subject><subject>Drug Interactions</subject><subject>Fas antigen</subject><subject>fas Receptor</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mortality</subject><subject>Q1</subject><subject>Q2</subject><subject>Receptors, Tumor Necrosis Factor - metabolism</subject><subject>TCDD</subject><subject>Thymocytes</subject><subject>Thymus Gland - drug effects</subject><subject>Thymus Gland - metabolism</subject><issn>0141-5492</issn><issn>1573-6776</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkc2KFDEURoMoTjv6AG4kCIObjuavkqplMzg6MKALXYdUkurOUJWUSYqZ8tV8OdN2w4CLEC6c7-NyDwBvCf5IMJafMsEN7RDGHLW044g-AxvSSIaElOI52GDCCWp4Ry_Aq5zvMcadxPIluKgQp4SLDfizg0anPh5Wm3RxcEjaFB_DFu5uv5NtneMEd6m4yWevoX_Qa5zi3kMbHwJKbr-MNZbhjc5w74KD7nFOLudaAXWwMC_zv7kieo5zicUbaJ0uBxgHWA6uvnWKZj2W-GAX4yzsV0i3bCu3LSrOlLrSYYwpWt-78DuiGVkfH314DV4Meszuzfm_BD9vPv-4_oruvn25vd7dIcMbXpDmvDeYaqabhuHe9qQXmJnBaUsol7rVjAwDFbzDjOLOCSKFEP3ABROEyIZdgg-n3jnFX4vLRdVjGDeOOri4ZCV5Izom27aS7_8j7-OSQl1OScZbwVlzhMgJMinmnNyg5uQnnVZFsDp6VSevqnpVR6-K1sy7c_HST84-Jc4iK3B1BnQ2eqwag_H5iROCypZL9hfVM6zL</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Ji, Hee Jung</creator><creator>Yeo, Hee Kyoung</creator><creator>Lee, Nam Hee</creator><creator>Hwang, Jung Suk</creator><creator>Koo, Kyung Ah</creator><creator>Cheong, Seon Woo</creator><creator>Park, Joo Hung</creator><creator>Oh, Gap Soo</creator><creator>Yoon, Chun Sik</creator><creator>Youn, Hyun Joo</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>Q9U</scope></search><sort><creationdate>20050201</creationdate><title>A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin</title><author>Ji, Hee Jung ; Yeo, Hee Kyoung ; Lee, Nam Hee ; Hwang, Jung Suk ; Koo, Kyung Ah ; Cheong, Seon Woo ; Park, Joo Hung ; Oh, Gap Soo ; Yoon, Chun Sik ; Youn, Hyun Joo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-a44bc02a3a5530bdb1b603cfead1247a8a31ff264903209e617666bf463611753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - physiology</topic><topic>Artemisia - metabolism</topic><topic>Artemisia iwayomogi</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Carbohydrates</topic><topic>Carbohydrates - pharmacology</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - physiology</topic><topic>Cells, Cultured</topic><topic>Dioxins</topic><topic>Dioxins - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Down-Regulation - drug effects</topic><topic>Down-Regulation - physiology</topic><topic>Drug Interactions</topic><topic>Fas antigen</topic><topic>fas Receptor</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin</atitle><jtitle>Biotechnology letters</jtitle><addtitle>Biotechnol Lett</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>27</volume><issue>4</issue><spage>253</spage><epage>257</epage><pages>253-257</pages><issn>0141-5492</issn><eissn>1573-6776</eissn><coden>BILED3</coden><abstract>Apoptotic death of mouse thymocytes in vitro, as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas gene expression. We have now investigated whether the AIP1 fraction modulates TCDD-induced thymocyte death. When treated with TCDD and AIP1 fraction together, the thymocytes do not show apoptosis induced by the TCDD treatment. The AIP1 supplementation to the TCDD treatment also down-regulates the TCDD-induced Fas gene up-regulation. These findings indicate that the AIP1 fraction suppresses TCDD-induced thymocyte apoptosis through the modulation of Fas gene expression.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>15742146</pmid><doi>10.1007/s10529-004-8294-2</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Artemisia - metabolism Artemisia iwayomogi Biological and medical sciences Biotechnology Carbohydrates Carbohydrates - pharmacology Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Dioxins Dioxins - pharmacology Dose-Response Relationship, Drug Down-Regulation - drug effects Down-Regulation - physiology Drug Interactions Fas antigen fas Receptor Female Fundamental and applied biological sciences. Psychology Gene expression Mice Mice, Inbred C57BL Mortality Q1 Q2 Receptors, Tumor Necrosis Factor - metabolism TCDD Thymocytes Thymus Gland - drug effects Thymus Gland - metabolism |
| title | A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin |
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