Efficient Activation of LRH-1―specific CD8+ T-cell Responses From Transplanted Leukemia Patients by Stimulation With P2X5 mRNA-electroporated Dendritic Cells

Alloreactive CD8+ T cells targeting minor histocompatibility antigens (MiHA) on malignant cells of the recipient play a pivotal role in graft-versus-tumor responses observed after allogeneic stem cell transplantation and donor lymphocyte infusion (DLI). However, these MiHA-specific CD8+ T-cell respo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of immunotherapy 2009-07, Vol.32 (6), p.539-551
Hauptverfasser:	OVERES, Ingrid M, FREDRIX, Hanny, KESTER, Michel G. D, FREDERIK FALKENBURG, J. H, VAN DER VOORT, Robbert, DE WITTE, Theo M, DOLSTRA, Harry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Antineoplastic agents Biological and medical sciences CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell activation Cell Degranulation - immunology Cell migration Dendritic cells Dendritic Cells - immunology Dendritic Cells - transplantation Donors Effector cells Electroporation gamma -Interferon Gene expression Graft vs Leukemia Effect Graft-versus-host reaction Hematologic and hematopoietic diseases Humans Immunological memory Immunotherapy Interferon-gamma - biosynthesis Interferon-gamma - immunology Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy Leukemia, Myeloid, Acute - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes T Medical sciences Memory cells Minor histocompatibility antigens Minor Histocompatibility Antigens - immunology mRNA Peripheral blood mononuclear cells Pharmacology. Drug treatments Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - immunology Receptors, Purinergic P2X5 RNA, Messenger - genetics Stem Cell Transplantation Tumor cells Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!