Expression of a single-chain human interleukin-12 gene in transgenic tobacco plants and functional studies

Interleukin 12 (IL-12) is a key heterodimeric cytokine produced by a variety of antigen-presenting cells, including dendritic cells, macrophages, and B cells. It displays a potent array of biological activities affecting natural killer (NK) and T cells. These activities include promotion of cell-med...

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Veröffentlicht in:	Biotechnology and bioengineering 2004-03, Vol.85 (7), p.734-740
Hauptverfasser:	Gutierrez-Ortega, A, Avila-Moreno, F, Saucedo-Arias, L.J, Sanchez-Torres, C, Gomez-Lim, M.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen-presenting cells Antineoplastic drugs. Cytokines Biological and medical sciences biological production Biotechnology Cancer Cells, Cultured Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Plant - physiology genetic engineering Health. Pharmaceutical industry Humans Immunotherapy Industrial applications and implications. Economical aspects interferon gamma Interferon-gamma - biosynthesis Interleukin 12 Interleukin-12 - biosynthesis Interleukin-12 - chemistry Interleukin-12 - genetics Interleukin-12 - pharmacology Killer Cells, Natural - drug effects Killer Cells, Natural - metabolism Molecular Weight Nicotiana - genetics Nicotiana - metabolism Nicotiana tabacum NK cells Plants, Genetically Modified - metabolism Production of active biomolecules Protein Engineering - methods Q1 Q2 recombinant proteins Recombinant Proteins - biosynthesis Recombinant Proteins - pharmacology Transgenic plants
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