Effects of the Antifungal Agent Itraconazole on Proliferative Changes of the Forestomach Mucosa in Alloxan-induced Diabetic Rats

Alloxan-induced diabetic rats frequently exhibit proliferative lesions of squamous hyperplasia accompanied by chronic inflammation and Candida albicans infection in the forestomach, and some lesions progress to squamous cell carcinoma (SCC). Candida infection causes not only hyperplastic changes wit...

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Veröffentlicht in:	Toxicologic pathology 2009-10, Vol.37 (6), p.790-798
Hauptverfasser:	Sano, Tomoya, Ozaki, Kiyokazu, Kodama, Yasushi, Matsuura, Tetsuro, Narama, Isao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - pharmacology Biological and medical sciences Candida albicans Candidiasis - drug therapy Candidiasis - metabolism Candidiasis - pathology Cell Growth Processes - drug effects Cyclooxygenase 2 - metabolism Dermatology Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - microbiology Diabetes Mellitus, Experimental - pathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - microbiology Gastric Mucosa - pathology Glycosuria - drug therapy Glycosuria - metabolism Glycosuria - microbiology Glycosuria - pathology Histocytochemistry Hyperglycemia - drug therapy Hyperglycemia - metabolism Hyperglycemia - microbiology Hyperglycemia - pathology Hyperplasia Itraconazole - pharmacology Medical sciences Proliferating Cell Nuclear Antigen - metabolism Rats Toxicology Tumors of the skin and soft tissue. Premalignant lesions
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