Cyproheptadine resembles clozapine in vivo following both acute and chronic administration in rats

Cyproheptadine is a cheap, widely available anti-allergy drug with a broad receptor binding profile which resembles that of clozapine. In rats discriminating clozapine from vehicle cyproheptadine mimicked clozapine very closely. Acutely it induced full generalization in the absence of response suppr...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2007-03, Vol.21 (2), p.179-190
Hauptverfasser:	Goudie, Andrew J., Cooper, Gillian D., Cole, Jon C., Sumnall, Harry R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Animals Anti-Allergic Agents - administration & dosage Anti-Allergic Agents - pharmacology Antipsychotic Agents - administration & dosage Antipsychotic Agents - pharmacology Antipsychotics Biological and medical sciences Chlordiazepoxide Clozapine Clozapine - administration & dosage Clozapine - pharmacology Comparative analysis Conditioning, Operant - drug effects Cross-tolerance Cyproheptadine Cyproheptadine - administration & dosage Cyproheptadine - pharmacology Discrimination (Psychology) - drug effects Discrimination Learning - drug effects Dosage and administration Dose-Response Relationship, Drug Drug Tolerance Dyskinesia, Drug-Induced Female Generalization (Psychology) - drug effects Medical sciences Mental disorders Neuropharmacology Pharmaceutical Vehicles Pharmacodynamics Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Rodents Schizophrenia Side effects Substance Withdrawal Syndrome Weight Gain - drug effects
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