Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma
Background Plasma organochlorines have been implicated to increase the risk of non-Hodgkin lymphoma (NHL), and interaction with the aryl hydrocarbon receptor gene (AHR) may modify this risk. Methods In this case-control study conducted in British Columbia, Canada, five single nucleotide polymorphism...
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| Veröffentlicht in: | Cancer causes & control 2010-01, Vol.21 (1), p.11-22 |
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| creator | Ng, Carmen H Janoo-Gilani, Rozmin Sipahimalani, Payal Gallagher, Richard P Gascoyne, Randy D Connors, Joseph M Weber, Jean-Philippe Lai, Agnes S Leach, Stephen Le, Nhu D Brooks-Wilson, Angela R Spinelli, John J |
| description | Background Plasma organochlorines have been implicated to increase the risk of non-Hodgkin lymphoma (NHL), and interaction with the aryl hydrocarbon receptor gene (AHR) may modify this risk. Methods In this case-control study conducted in British Columbia, Canada, five single nucleotide polymorphisms (SNPs) of AHR were genotyped in 422 NHL cases and 459 controls to measure the association between individual SNPs, haplotypes, and risk of NHL. Pre-chemotherapy organochlorine levels were measured and gene-environment interaction analysis was performed. Results The IVS1 + 4640G/A SNP was significantly associated with NHL risk, with an odds ratio of 1.32 (95% CI = 1.05-1.65) for G/A or A/A genotypes compared to the G/G genotype. Interactions were observed with PCB 118, a known inducer of AHR, and chlordane-related analytes oxychlordane and trans-nonachlor, although no interactions were statistically significant after controlling for multiple comparisons. The observed interactions were consistent across NHL subtypes. Conclusion Results suggest that the AHR gene may play a role in determining the risk of NHL with exposure to organochlorines, and highlight the importance of understanding gene-environment interactions. |
| doi_str_mv | 10.1007/s10552-009-9429-5 |
| format | Article |
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Methods In this case-control study conducted in British Columbia, Canada, five single nucleotide polymorphisms (SNPs) of AHR were genotyped in 422 NHL cases and 459 controls to measure the association between individual SNPs, haplotypes, and risk of NHL. Pre-chemotherapy organochlorine levels were measured and gene-environment interaction analysis was performed. Results The IVS1 + 4640G/A SNP was significantly associated with NHL risk, with an odds ratio of 1.32 (95% CI = 1.05-1.65) for G/A or A/A genotypes compared to the G/G genotype. Interactions were observed with PCB 118, a known inducer of AHR, and chlordane-related analytes oxychlordane and trans-nonachlor, although no interactions were statistically significant after controlling for multiple comparisons. The observed interactions were consistent across NHL subtypes. Conclusion Results suggest that the AHR gene may play a role in determining the risk of NHL with exposure to organochlorines, and highlight the importance of understanding gene-environment interactions.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/s10552-009-9429-5</identifier><identifier>PMID: 19821039</identifier><identifier>CODEN: CCCNEN</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : Springer Netherlands</publisher><subject>Adult ; Aged ; Alleles ; Aryl hydrocarbon receptors ; Basic Helix-Loop-Helix Transcription Factors ; Biomedical and Life Sciences ; Biomedicine ; British Columbia ; Cancer ; Cancer Research ; Case-Control Studies ; Chemotherapy ; Dioxins ; Environmental Exposure ; Environmental Pollutants - blood ; Epidemiology ; Exons ; Genes ; Genetic Predisposition to Disease ; Genetic testing ; Genotype ; Genotypes ; Haplotypes ; Hematology ; Humans ; Hydrocarbons ; Hydrocarbons, Chlorinated - blood ; Kinases ; Lymphoma ; Lymphoma, Non-Hodgkin - epidemiology ; Lymphoma, Non-Hodgkin - genetics ; Middle Aged ; Non Hodgkin lymphoma ; Oncology ; Original Paper ; PCB ; Pesticides ; Plasma ; Polychlorinated biphenyls ; Polymorphism, Single Nucleotide ; Public Health ; Receptors, Aryl Hydrocarbon - genetics ; Risk Factors ; Sequencing ; T lymphocytes ; Toxicity</subject><ispartof>Cancer causes & control, 2010-01, Vol.21 (1), p.11-22</ispartof><rights>Copyright 2010 Springer</rights><rights>Springer Science+Business Media B.V. 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-b2a93c83897087a9aa1596e42c456612be31a5ba5074671e8d06fbee766845b33</citedby><cites>FETCH-LOGICAL-c514t-b2a93c83897087a9aa1596e42c456612be31a5ba5074671e8d06fbee766845b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25621323$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25621323$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,27905,27906,41469,42538,51300,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19821039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, Carmen H</creatorcontrib><creatorcontrib>Janoo-Gilani, Rozmin</creatorcontrib><creatorcontrib>Sipahimalani, Payal</creatorcontrib><creatorcontrib>Gallagher, Richard P</creatorcontrib><creatorcontrib>Gascoyne, Randy D</creatorcontrib><creatorcontrib>Connors, Joseph M</creatorcontrib><creatorcontrib>Weber, Jean-Philippe</creatorcontrib><creatorcontrib>Lai, Agnes S</creatorcontrib><creatorcontrib>Leach, Stephen</creatorcontrib><creatorcontrib>Le, Nhu D</creatorcontrib><creatorcontrib>Brooks-Wilson, Angela R</creatorcontrib><creatorcontrib>Spinelli, John J</creatorcontrib><title>Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><addtitle>Cancer Causes Control</addtitle><description>Background Plasma organochlorines have been implicated to increase the risk of non-Hodgkin lymphoma (NHL), and interaction with the aryl hydrocarbon receptor gene (AHR) may modify this risk. Methods In this case-control study conducted in British Columbia, Canada, five single nucleotide polymorphisms (SNPs) of AHR were genotyped in 422 NHL cases and 459 controls to measure the association between individual SNPs, haplotypes, and risk of NHL. Pre-chemotherapy organochlorine levels were measured and gene-environment interaction analysis was performed. Results The IVS1 + 4640G/A SNP was significantly associated with NHL risk, with an odds ratio of 1.32 (95% CI = 1.05-1.65) for G/A or A/A genotypes compared to the G/G genotype. Interactions were observed with PCB 118, a known inducer of AHR, and chlordane-related analytes oxychlordane and trans-nonachlor, although no interactions were statistically significant after controlling for multiple comparisons. The observed interactions were consistent across NHL subtypes. Conclusion Results suggest that the AHR gene may play a role in determining the risk of NHL with exposure to organochlorines, and highlight the importance of understanding gene-environment interactions.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Aryl hydrocarbon receptors</subject><subject>Basic Helix-Loop-Helix Transcription Factors</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>British Columbia</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Chemotherapy</subject><subject>Dioxins</subject><subject>Environmental Exposure</subject><subject>Environmental Pollutants - blood</subject><subject>Epidemiology</subject><subject>Exons</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic testing</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Haplotypes</subject><subject>Hematology</subject><subject>Humans</subject><subject>Hydrocarbons</subject><subject>Hydrocarbons, Chlorinated - blood</subject><subject>Kinases</subject><subject>Lymphoma</subject><subject>Lymphoma, Non-Hodgkin - epidemiology</subject><subject>Lymphoma, Non-Hodgkin - genetics</subject><subject>Middle Aged</subject><subject>Non Hodgkin lymphoma</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>PCB</subject><subject>Pesticides</subject><subject>Plasma</subject><subject>Polychlorinated biphenyls</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Public Health</subject><subject>Receptors, Aryl Hydrocarbon - genetics</subject><subject>Risk Factors</subject><subject>Sequencing</subject><subject>T lymphocytes</subject><subject>Toxicity</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkUGP1CAYhonRuOPqD_CgEi9eRD-gQDluNupssomJul4J7XztdLaFETox--9l7MRNPOiJBJ73hY-HkOcc3nEA8z5zUEowAMtsJSxTD8iKKyOZEUI9JCuwyjAlKnlGnuS8AwClBTwmZ9zWgoO0K_L9KsyYfDsPMdAG55-IgcbU-xDb7RjTEDBTHzZ03iK9WH-hPQZ8-3snDfmWxo6GGNg6bvrbIdDxbtpv4-SfkkedHzM-O63n5Objh2-Xa3b9-dPV5cU1axWvZtYIb2Vby9oaqI233nNlNVairZTWXDQouVeNV2AqbTjWG9Bdg2i0rivVSHlO3iy9-xR_HDDPbhpyi-PoA8ZDdqb01Mfs_0kpy5OUtIV8_Re5i4cUyhhOcAlaaiUKxBeoTTHnhJ3bp2Hy6c5xcEc5bpHjihx3lONUybw8FR-aCTf3iZONAogFyOUo9Jjub_5X64sltMtzTH9KRVHNpTh-0avlvPPR-b5YczdfBZRJuBFG1Vb-AicoqkU</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Ng, Carmen H</creator><creator>Janoo-Gilani, Rozmin</creator><creator>Sipahimalani, Payal</creator><creator>Gallagher, Richard P</creator><creator>Gascoyne, Randy D</creator><creator>Connors, Joseph M</creator><creator>Weber, Jean-Philippe</creator><creator>Lai, Agnes S</creator><creator>Leach, Stephen</creator><creator>Le, Nhu D</creator><creator>Brooks-Wilson, Angela R</creator><creator>Spinelli, John J</creator><general>Dordrecht : Springer Netherlands</general><general>Springer</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7T5</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20100101</creationdate><title>Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma</title><author>Ng, Carmen H ; Janoo-Gilani, Rozmin ; Sipahimalani, Payal ; Gallagher, Richard P ; Gascoyne, Randy D ; Connors, Joseph M ; Weber, Jean-Philippe ; Lai, Agnes S ; Leach, Stephen ; Le, Nhu D ; Brooks-Wilson, Angela R ; Spinelli, John J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-b2a93c83897087a9aa1596e42c456612be31a5ba5074671e8d06fbee766845b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Aryl hydrocarbon receptors</topic><topic>Basic Helix-Loop-Helix Transcription Factors</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>British Columbia</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Chemotherapy</topic><topic>Dioxins</topic><topic>Environmental Exposure</topic><topic>Environmental Pollutants - blood</topic><topic>Epidemiology</topic><topic>Exons</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic testing</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Haplotypes</topic><topic>Hematology</topic><topic>Humans</topic><topic>Hydrocarbons</topic><topic>Hydrocarbons, Chlorinated - blood</topic><topic>Kinases</topic><topic>Lymphoma</topic><topic>Lymphoma, Non-Hodgkin - epidemiology</topic><topic>Lymphoma, Non-Hodgkin - genetics</topic><topic>Middle Aged</topic><topic>Non Hodgkin lymphoma</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>PCB</topic><topic>Pesticides</topic><topic>Plasma</topic><topic>Polychlorinated biphenyls</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Public Health</topic><topic>Receptors, Aryl Hydrocarbon - genetics</topic><topic>Risk Factors</topic><topic>Sequencing</topic><topic>T lymphocytes</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ng, Carmen H</creatorcontrib><creatorcontrib>Janoo-Gilani, Rozmin</creatorcontrib><creatorcontrib>Sipahimalani, Payal</creatorcontrib><creatorcontrib>Gallagher, Richard P</creatorcontrib><creatorcontrib>Gascoyne, Randy D</creatorcontrib><creatorcontrib>Connors, Joseph M</creatorcontrib><creatorcontrib>Weber, Jean-Philippe</creatorcontrib><creatorcontrib>Lai, Agnes S</creatorcontrib><creatorcontrib>Leach, Stephen</creatorcontrib><creatorcontrib>Le, Nhu D</creatorcontrib><creatorcontrib>Brooks-Wilson, Angela R</creatorcontrib><creatorcontrib>Spinelli, John J</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Cancer causes & control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng, Carmen H</au><au>Janoo-Gilani, Rozmin</au><au>Sipahimalani, Payal</au><au>Gallagher, Richard P</au><au>Gascoyne, Randy D</au><au>Connors, Joseph M</au><au>Weber, Jean-Philippe</au><au>Lai, Agnes S</au><au>Leach, Stephen</au><au>Le, Nhu D</au><au>Brooks-Wilson, Angela R</au><au>Spinelli, John J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma</atitle><jtitle>Cancer causes & control</jtitle><stitle>Cancer Causes Control</stitle><addtitle>Cancer Causes Control</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>21</volume><issue>1</issue><spage>11</spage><epage>22</epage><pages>11-22</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><coden>CCCNEN</coden><abstract>Background Plasma organochlorines have been implicated to increase the risk of non-Hodgkin lymphoma (NHL), and interaction with the aryl hydrocarbon receptor gene (AHR) may modify this risk. Methods In this case-control study conducted in British Columbia, Canada, five single nucleotide polymorphisms (SNPs) of AHR were genotyped in 422 NHL cases and 459 controls to measure the association between individual SNPs, haplotypes, and risk of NHL. Pre-chemotherapy organochlorine levels were measured and gene-environment interaction analysis was performed. Results The IVS1 + 4640G/A SNP was significantly associated with NHL risk, with an odds ratio of 1.32 (95% CI = 1.05-1.65) for G/A or A/A genotypes compared to the G/G genotype. Interactions were observed with PCB 118, a known inducer of AHR, and chlordane-related analytes oxychlordane and trans-nonachlor, although no interactions were statistically significant after controlling for multiple comparisons. The observed interactions were consistent across NHL subtypes. Conclusion Results suggest that the AHR gene may play a role in determining the risk of NHL with exposure to organochlorines, and highlight the importance of understanding gene-environment interactions.</abstract><cop>Dordrecht</cop><pub>Dordrecht : Springer Netherlands</pub><pmid>19821039</pmid><doi>10.1007/s10552-009-9429-5</doi><tpages>12</tpages></addata></record> |
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| subjects | Adult Aged Alleles Aryl hydrocarbon receptors Basic Helix-Loop-Helix Transcription Factors Biomedical and Life Sciences Biomedicine British Columbia Cancer Cancer Research Case-Control Studies Chemotherapy Dioxins Environmental Exposure Environmental Pollutants - blood Epidemiology Exons Genes Genetic Predisposition to Disease Genetic testing Genotype Genotypes Haplotypes Hematology Humans Hydrocarbons Hydrocarbons, Chlorinated - blood Kinases Lymphoma Lymphoma, Non-Hodgkin - epidemiology Lymphoma, Non-Hodgkin - genetics Middle Aged Non Hodgkin lymphoma Oncology Original Paper PCB Pesticides Plasma Polychlorinated biphenyls Polymorphism, Single Nucleotide Public Health Receptors, Aryl Hydrocarbon - genetics Risk Factors Sequencing T lymphocytes Toxicity |
| title | Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma |
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