Stacking interactions of ApA analogues with modified backbones

CD spectra have been measured as a function of temperature for a number of ApA analogues with modified backbones. Oligonucleotides with these modified backbones are being used as antisense agents having potential as viral therapeutics. Results of these studies show that when a carbonyl is substitute...

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Veröffentlicht in:	Biopolymers 1992-10, Vol.32 (10), p.1351-1363
Hauptverfasser:	Kang, Hunseung, Chou, Ping-Jung, Johnson JR, W. Curtis, Weller, Dwight, Huang, Sung-Ben, Summerton, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Circular Dichroism Dinucleoside Phosphates - chemistry Fundamental and applied biological sciences. Psychology Molecular biophysics Molecular Structure Nucleic Acid Conformation Thermodynamics
Online-Zugang:	Volltext
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