Enantioselective microbial reduction of 3,5-dioxo-6-(benzyloxy) hexanoic acid, ethyl ester

The key chiral intermediate 3,5-dihydroxy-6-(benzyloxy) hexanoic acid, ethyl ester 2a, was made by the stereoselective microbial reduction of 3,5-dioxo-6-(benzyloxy) hexanoic acid, ethyl ester 1. Among various microbial cultures evaluated, cell suspensions of Acinetobacter calcoaceticus SC 13876 red...

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Veröffentlicht in:	Enzyme and microbial technology 1993, Vol.15 (12), p.1014-1021
Hauptverfasser:	Patel, Ramesh N., Banerjee, Amit, McNamee, Clyde G., Brzozowski, David, Hanson, Ronald L., Szarka, Laszlo J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,5-dioxo-6-(benzyloxy) hexanoic acid Acinetobacter calcoaceticus Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology ethyl ester Fundamental and applied biological sciences. Psychology HMG-CoA reductase inhibitor synthon Methods. Procedures. Technologies microbial reduction Stereoselective
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