Suboptimal adherence to darunavir/ritonavir has minimal effect on efficacy compared with lopinavir/ritonavir in treatment-naive, HIV-infected patients: 96 week ARTEMIS data

Objectives To examine how treatment adherence differences in ARTEMIS (96 week analysis) affected clinical outcome, and to assess factors impacting adherence. Patients and methods ARTEMIS is a Phase III trial, in HIV-1-infected treatment-naive patients, comparing efficacy and safety of once-daily dar...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2010-07, Vol.65 (7), p.1505-1509
Hauptverfasser:	Nelson, Mark, Girard, Pierre-Marie, DeMasi, Ralph, Chen, Liddy, Smets, Erik, Sekar, Vanitha, Lavreys, Ludo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Biological and medical sciences Chemotherapy Clinical outcomes Darunavir Drug therapy HIV HIV Infections - drug therapy HIV Infections - virology HIV-1 - isolation & purification Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Lopinavir Medical sciences Medication Adherence - statistics & numerical data Pharmacology. Drug treatments Phase III protease inhibitors Pyrimidinones - administration & dosage Pyrimidinones - adverse effects Ritonavir - administration & dosage Ritonavir - adverse effects Sulfonamides - administration & dosage Sulfonamides - adverse effects TMC114 treatment compliance Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virology
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