MicroRNA‐10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC

MicroRNAs (miRNAs) are effective post‐transcriptional regulators of gene expression and are important in many biological processes. Although the oncogenic and tumor suppressive functions of several miRNAs have been characterized, the role of miRNAs in mediating tumor invasion and migration remains l...

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Veröffentlicht in:	International journal of cancer 2009-09, Vol.125 (6), p.1407-1413
Hauptverfasser:	Sasayama, Takashi, Nishihara, Masamitsu, Kondoh, Takeshi, Hosoda, Kohkichi, Kohmura, Eiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Brain Neoplasms - genetics Brain Neoplasms - pathology Gene Expression Regulation, Neoplastic - physiology glioma Glioma - genetics Glioma - pathology Humans Immunoenzyme Techniques invasion Medical sciences Membrane Glycoproteins - genetics miR‐10b Neoplasm Invasiveness Neoplasm Staging Neurology Oligonucleotide Array Sequence Analysis Receptors, Immunologic - genetics Receptors, Urokinase Plasminogen Activator - genetics Reverse Transcriptase Polymerase Chain Reaction rho GTP-Binding Proteins - genetics RhoC rhoC GTP-Binding Protein RNA, Messenger - genetics RNA, Messenger - metabolism Tumor Cells, Cultured Tumors Tumors of the nervous system. Phacomatoses Up-Regulation uPAR
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