Oral and pulmonary delivery of FSH–Fc fusion proteins via neonatal Fc receptor-mediated transcytosis

BACKGROUND: The α and β subunits of FSH were fused to the Fc domain of IgG1 either in a single chain or a heterodimer format. These molecules were absorbed through the epithelium in lung and intestine by neonatal Fc receptor (FcRn)-mediated transcytosis. METHODS AND RESULTS: Single chain and heterod...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human reproduction (Oxford) 2005-07, Vol.20 (7), p.1805-1813
Hauptverfasser:	Low, S.C., Nunes, S.L., Bitonti, A.J., Dumont, J.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aerosols Animals Animals, Newborn Base Sequence Biological and medical sciences Biological Transport, Active CHO Cells Cricetinae Cynomolgus DNA, Complementary - genetics FcRn Female Follicle Stimulating Hormone - administration & dosage Follicle Stimulating Hormone - pharmacokinetics FSH Gynecology. Andrology. Obstetrics Humans Immunoglobulin Fc Fragments - administration & dosage Immunoglobulin Fc Fragments - metabolism lung Macaca fascicularis Male Medical sciences Organ Size - drug effects Ovary - anatomy & histology Ovary - drug effects pulmonary delivery Rats Receptors, Fc - metabolism Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - pharmacokinetics Testis - anatomy & histology Testis - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!