Heterogeneous ribonucleoprotein K is a marker of oral leukoplakia and correlates with poor prognosis of squamous cell carcinoma

Oral leukoplakia is a heterogeneous lesion with risk of cancer development; there are no biomarkers to predict its potential of malignant transformation. Tissue proteomic analysis of oral leukoplakia using iTRAQ labeling liquid chromatography–mass spectrometry showed overexpression of heterogeneous...

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Veröffentlicht in:	International journal of cancer 2009-09, Vol.125 (6), p.1398-1406
Hauptverfasser:	Matta, Ajay, Tripathi, Satyendra Chandra, DeSouza, Leroi V., Grigull, Jörg, Kaur, Jatinder, Chauhan, Shyam Singh, Srivastava, Anurag, Thakar, Alok, Shukla, Nootan Kumar, Duggal, Ritu, DattaGupta, Siddhartha, Ralhan, Ranju, Michael Siu, K.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Case-Control Studies Female head‐and‐neck cancer Heterogeneous-Nuclear Ribonucleoprotein K hnRNP K Humans Immunoenzyme Techniques Leukoplakia, Oral - diagnosis Leukoplakia, Oral - genetics Leukoplakia, Oral - metabolism Male Medical sciences Middle Aged Neoplasm Staging oral leukoplakia Otorhinolaryngology. Stomatology Prognosis Reverse Transcriptase Polymerase Chain Reaction Ribonucleoproteins - genetics Ribonucleoproteins - metabolism Risk Factors RNA, Messenger - genetics RNA, Messenger - metabolism squamous cell carcinoma Survival Rate Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Young Adult
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