The proto‐oncogene BCL6 promotes survival of olfactory sensory neurons

For the mammalian olfactory epithelium to continually detect odorant, neuronal survival, apoptosis, and regeneration must be coordinated. Here, we showed that the proto‐oncogene BCL6, which encodes a transcriptional repressor required for lymphocyte terminal differentiation, contributes to the survi...

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Veröffentlicht in:	Developmental neurobiology (Hoboken, N.J.) N.J.), 2010-05, Vol.70 (6), p.424-435
Hauptverfasser:	Otaki, Joji M., Hatano, Masahiko, Matayoshi, Rie, Tokuhisa, Takeshi, Yamamoto, Haruhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - physiology BCL6 cell survival Cell Survival - physiology DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism GAP-43 Protein - genetics GAP-43 Protein - metabolism Gene Expression Lectins - metabolism Mice Mice, Knockout Olfactory Marker Protein - genetics Olfactory Marker Protein - metabolism Olfactory Mucosa - pathology Olfactory Mucosa - physiology olfactory sensory neuron Organ Size Proto-Oncogene Proteins c-bcl-6 Receptors, Odorant - genetics Receptors, Odorant - metabolism regeneration Sensory Receptor Cells - pathology Sensory Receptor Cells - physiology
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