Induction of chemoresistance in a cultured canine cell line by retroviral transduction of the canine multidrug resistance 1 gene

To induce chemoresistance in a normal canine cell line through the transduction of the canine multidrug resistance 1 gene (mdr1). Madin-Darby canine kidney (MDCK) epithelial cell line. The full-length canine mdr1 cDNA clone isolated in our laboratory was inserted into a Moloney murine leukemia virus...

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Veröffentlicht in:	American journal of veterinary research 2007, Vol.68 (1), p.95-100
Hauptverfasser:	Matsuura, S, Koto, H, Ide, K, Fujino, Y, Setoguchi-Mukai, A, Ohno, K, Tsujimoto, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Base Sequence Cell Line cell lines Cercopithecus aethiops complementary DNA COS Cells cultured cells DNA, Complementary - genetics dogs Dogs - genetics Dogs - metabolism Doxorubicin - pharmacology drug resistance Drug Resistance, Neoplasm epithelium Flow Cytometry - veterinary Fluorescent Dyes - metabolism genes genetic transduction Genetic Vectors - genetics Inhibitory Concentration 50 Molecular Sequence Data multiple drug resistance retroviral vectors Retroviridae - genetics Rhodamine 123 - metabolism Sequence Analysis, DNA Transduction, Genetic - veterinary Vincristine - pharmacology
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