Involvement of TRPA1 in ET-1-induced pain-like behavior in mice
Transient receptor potential ankyrin subfamily member 1 (TRPA1) is a nonselective cation channel known as a noxious cold-activated ion channel. Recent findings implicated its involvement in acute and chronic cold nociception processes. Here, we investigated whether TRPA1 is involved in endothelin-1...
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| Veröffentlicht in: | Neuroreport 2010-02, Vol.21 (3), p.201-205 |
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| creator | Liang, Jiexian Bi, Hua Ji, Wenjin |
| description | Transient receptor potential ankyrin subfamily member 1 (TRPA1) is a nonselective cation channel known as a noxious cold-activated ion channel. Recent findings implicated its involvement in acute and chronic cold nociception processes. Here, we investigated whether TRPA1 is involved in endothelin-1 (ET-1)-induced spontaneous pain-like behavior in C57BL/6J mice. We found that TRPA1 antagonists, HC-030031 and AP18, significantly reduced the pain-like behavior caused by ET-1. AP18 also significantly reduced the pain caused by cinnamaldehyde, an agonist of TRPA-1. However, AP18 did not alleviate the pain caused by capsaicin. The pain-like behavior caused by ET-1 was inhibited by phospholipase C inhibitor, but not by protein kinase C inhibitor. Low dose of ET-1 could potentiate cinnamaldehyde-induced nociception. Our results suggested that TRPA1 is involved in ET-1-induced spontaneous pain-like behavior in mice. |
| doi_str_mv | 10.1097/WNR.0b013e328335b3c5 |
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Recent findings implicated its involvement in acute and chronic cold nociception processes. Here, we investigated whether TRPA1 is involved in endothelin-1 (ET-1)-induced spontaneous pain-like behavior in C57BL/6J mice. We found that TRPA1 antagonists, HC-030031 and AP18, significantly reduced the pain-like behavior caused by ET-1. AP18 also significantly reduced the pain caused by cinnamaldehyde, an agonist of TRPA-1. However, AP18 did not alleviate the pain caused by capsaicin. The pain-like behavior caused by ET-1 was inhibited by phospholipase C inhibitor, but not by protein kinase C inhibitor. Low dose of ET-1 could potentiate cinnamaldehyde-induced nociception. Our results suggested that TRPA1 is involved in ET-1-induced spontaneous pain-like behavior in mice.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/WNR.0b013e328335b3c5</identifier><identifier>PMID: 20042899</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Acrolein - analogs & derivatives ; Acrolein - toxicity ; Animals ; Behavior, Animal ; Endothelin-1 - metabolism ; Endothelin-1 - toxicity ; Enzyme Inhibitors - pharmacology ; Irritants - metabolism ; Irritants - toxicity ; Male ; Mice ; Mice, Inbred C57BL ; Pain - chemically induced ; Pain - metabolism ; Transient Receptor Potential Channels - metabolism ; TRPA1 Cation Channel</subject><ispartof>Neuroreport, 2010-02, Vol.21 (3), p.201-205</ispartof><rights>2010 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20042899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Jiexian</creatorcontrib><creatorcontrib>Bi, Hua</creatorcontrib><creatorcontrib>Ji, Wenjin</creatorcontrib><title>Involvement of TRPA1 in ET-1-induced pain-like behavior in mice</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>Transient receptor potential ankyrin subfamily member 1 (TRPA1) is a nonselective cation channel known as a noxious cold-activated ion channel. 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Our results suggested that TRPA1 is involved in ET-1-induced spontaneous pain-like behavior in mice.</description><subject>Acrolein - analogs & derivatives</subject><subject>Acrolein - toxicity</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Endothelin-1 - metabolism</subject><subject>Endothelin-1 - toxicity</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Irritants - metabolism</subject><subject>Irritants - toxicity</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Pain - chemically induced</subject><subject>Pain - metabolism</subject><subject>Transient Receptor Potential Channels - metabolism</subject><subject>TRPA1 Cation Channel</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLAzEUhYMotlb_gcjsXKXeNMlMspIiVQtFpVR0FzKZO3Rs5uE8Wvz3TmnduLpn8XE49yPkmsGYgY7uPl6WY4iBceQTxbmMuZMnZMhExKmU6vOUDEFLTYUO5YBcNM0XAGhg6pwMJgBiorQekvt5sS39FnMs2qBMg9XybcqCrAhmK8poViSdwySobFZQn20wiHFtt1lZ75E8c3hJzlLrG7w63hF5f5ytHp7p4vVp_jBd0IopLWmsJbDICS15HyyCC0GmAhPHEi1FAhD2mwULrQuVSxHSRMY2TaNQqEhazUfk9tBb1eV3h01r8qxx6L0tsOwaEwkZCoi06MmbI9nFOSamqrPc1j_m7-ceUAdgV_oW62bjux3WZo3Wt2vDwOz1ml6v-a-X_wK0JWow</recordid><startdate>20100217</startdate><enddate>20100217</enddate><creator>Liang, Jiexian</creator><creator>Bi, Hua</creator><creator>Ji, Wenjin</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope></search><sort><creationdate>20100217</creationdate><title>Involvement of TRPA1 in ET-1-induced pain-like behavior in mice</title><author>Liang, Jiexian ; Bi, Hua ; Ji, Wenjin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1895-b95017c4953501ae0c605f4edc1d954d006558416ac68cfe0fd5baff764875a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acrolein - analogs & derivatives</topic><topic>Acrolein - toxicity</topic><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Endothelin-1 - metabolism</topic><topic>Endothelin-1 - toxicity</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Irritants - metabolism</topic><topic>Irritants - toxicity</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Pain - chemically induced</topic><topic>Pain - metabolism</topic><topic>Transient Receptor Potential Channels - metabolism</topic><topic>TRPA1 Cation Channel</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Jiexian</creatorcontrib><creatorcontrib>Bi, Hua</creatorcontrib><creatorcontrib>Ji, Wenjin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Jiexian</au><au>Bi, Hua</au><au>Ji, Wenjin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of TRPA1 in ET-1-induced pain-like behavior in mice</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2010-02-17</date><risdate>2010</risdate><volume>21</volume><issue>3</issue><spage>201</spage><epage>205</epage><pages>201-205</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>Transient receptor potential ankyrin subfamily member 1 (TRPA1) is a nonselective cation channel known as a noxious cold-activated ion channel. 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| subjects | Acrolein - analogs & derivatives Acrolein - toxicity Animals Behavior, Animal Endothelin-1 - metabolism Endothelin-1 - toxicity Enzyme Inhibitors - pharmacology Irritants - metabolism Irritants - toxicity Male Mice Mice, Inbred C57BL Pain - chemically induced Pain - metabolism Transient Receptor Potential Channels - metabolism TRPA1 Cation Channel |
| title | Involvement of TRPA1 in ET-1-induced pain-like behavior in mice |
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