Inhibition of the Interferon-Inducible Protein Kinase PKR by HCV E2 Protein

Most isolates of hepatitis C virus (HCV) infections are resistant to interferon, the only available therapy, but the mechanism underlying this resistance has not been defined. Here it is shown that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1999-07, Vol.285 (5424), p.107-110
Hauptverfasser:	Taylor, Deborah R., Shi, Stephanie T., Romano, Patrick R., Barber, Glen N., Michael M. C. Lai
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Cell growth Cell Line Cellular immunity Chloramphenicol O-Acetyltransferase - biosynthesis Drug resistance Drug Resistance, Microbial Drug therapy eIF-2 Kinase - antagonists & inhibitors eIF-2 Kinase - chemistry eIF-2 Kinase - metabolism Endoplasmic Reticulum - metabolism Enzyme Induction Eukaryotic Initiation Factor-2 - chemistry Eukaryotic Initiation Factor-2 - metabolism Fundamental and applied biological sciences. Psychology Genotypes HeLa Cells Hepacivirus - drug effects Hepatitis Hepatitis C virus Humans Infections Inhibition Interferon Interferon-alpha - pharmacology Leaders Microbiology Phosphorylation Plasmids Protein Biosynthesis Protein kinases Protein synthesis Proteins Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains RNA Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Transfection Transformation, Genetic Translation Viral Envelope Proteins - chemistry Viral Envelope Proteins - metabolism Viral Envelope Proteins - pharmacology Viral Envelope Proteins - physiology Virology Yeasts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!