Pharmacokinetics after administration of an injectable experimental long-acting parenteral formulation of doxycycline hyclate in goats

To determine the pharmacokinetics after SC administration of an experimental, long-acting parenteral formulation of doxycycline hyclate in a poloxamer-based matrix and after IV and IM administration of an aqueous formulation of doxycycline hyclate in goats. 30 clinically normal adult goats. Goats we...

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Veröffentlicht in:	American journal of veterinary research 2008-08, Vol.69 (8), p.1085-1090
Hauptverfasser:	Vargas, D, Gutierrez, L, Juarez, I, Gonzalez, F, Sumano, H
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Bacterial Infections - drug therapy Bacterial Infections - veterinary bioavailability Biological Availability biomarkers blood chemistry blood serum chemical concentration dosage doxycycline Doxycycline - administration & dosage Doxycycline - analogs & derivatives Doxycycline - pharmacokinetics Doxycycline - therapeutic use doxycycline hyclate drug evaluation drug formulations Goat Diseases - drug therapy Goats Half-Life Infusions, Parenteral - methods Injections intestines new drugs normal values pharmacokinetics subcutaneous injection veterinary drugs
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