Tea catechins reduce inflammatory reactions via mitogen-activated protein kinase pathways in toll-like receptor 2 ligand-stimulated dental pulp cells

In this study, we evaluated whether catechins could inhibit the expression of pro-inflammatory mediators induced by dental caries-related bacteria, Streptococci, or pathogen-associated molecular patterns (PAMPs) stimulation in human dental pulp fibroblasts (HDPF). We further determined the mechanism...

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Veröffentlicht in:	Life sciences (1973) 2010-04, Vol.86 (17), p.654-660
Hauptverfasser:	Hirao, Kouji, Yumoto, Hiromichi, Nakanishi, Tadashi, Mukai, Kayo, Takahashi, Kanako, Takegawa, Daisuke, Matsuo, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - pharmacology Catechin Catechin - analogs & derivatives Catechin - pharmacology Cells, Cultured Dental Pulp - cytology Dental Pulp - pathology Dental pulp fibroblast Enzyme-Linked Immunosorbent Assay Fibroblasts - drug effects Fibroblasts - immunology Humans Inflammation Inflammation - drug therapy Inflammation - immunology Inflammation Mediators - metabolism Ligands Mitogen-Activated Protein Kinases - metabolism Phosphorylation - drug effects Receptors, Pattern Recognition - immunology Reverse Transcriptase Polymerase Chain Reaction Signal pathway Signal Transduction - drug effects Streptococcus - immunology Tea - chemistry Toll-Like Receptor 2 - metabolism Up-Regulation - drug effects
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