Prevalence of antigliadin antibodies in patients with psoriasis is not elevated compared with controls
Antigliadin antibodies (AGAs) are markers of celiac sprue but may have autoimmune implications in the absence of gastrointestinal disease. There is anecdotal evidence to suggest that gluten sensitivity may play a role in psoriasis, and patients with psoriasis in Europe have been reported to improve...
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| Veröffentlicht in: | American journal of clinical dermatology 2007-01, Vol.8 (5), p.301-305 |
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| container_title | American journal of clinical dermatology |
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| creator | KIA, Kevin F NAIR, Rajan P IKE, Robert W HIREMAGALORE, Ravi ELDER, James T ELLIS, Charles N |
| description | Antigliadin antibodies (AGAs) are markers of celiac sprue but may have autoimmune implications in the absence of gastrointestinal disease. There is anecdotal evidence to suggest that gluten sensitivity may play a role in psoriasis, and patients with psoriasis in Europe have been reported to improve on a gluten-free diet.
To assess whether patients with psoriasis in the US have an increased prevalence of elevated AGAs.
A US sample of patients with psoriasis (n=100), patients with psoriasis and psoriatic arthritis (n=100), and age-matched control individuals without any personal or family history of autoimmune disorders (n=100) were tested for IgG and IgA AGAs.
No difference in the prevalence of abnormal AGAs among patients with psoriasis (14%), combined psoriasis and psoriatic arthritis (18%), and control individuals (19%) was observed. No significant correlations between AGA positivity and psoriasis severity, joint involvement, or age of onset of psoriasis or arthritis were observed.
We found no support for the results of prior studies showing that elevated AGAs occur with increased frequency in patients with psoriasis. Furthermore, the relatively high prevalence of abnormal AGAs in our control population suggests these antibodies may not be associated with autoimmune disease. |
| doi_str_mv | 10.2165/00128071-200708050-00005 |
| format | Article |
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To assess whether patients with psoriasis in the US have an increased prevalence of elevated AGAs.
A US sample of patients with psoriasis (n=100), patients with psoriasis and psoriatic arthritis (n=100), and age-matched control individuals without any personal or family history of autoimmune disorders (n=100) were tested for IgG and IgA AGAs.
No difference in the prevalence of abnormal AGAs among patients with psoriasis (14%), combined psoriasis and psoriatic arthritis (18%), and control individuals (19%) was observed. No significant correlations between AGA positivity and psoriasis severity, joint involvement, or age of onset of psoriasis or arthritis were observed.
We found no support for the results of prior studies showing that elevated AGAs occur with increased frequency in patients with psoriasis. Furthermore, the relatively high prevalence of abnormal AGAs in our control population suggests these antibodies may not be associated with autoimmune disease.</description><identifier>ISSN: 1175-0561</identifier><identifier>EISSN: 1179-1888</identifier><identifier>DOI: 10.2165/00128071-200708050-00005</identifier><identifier>PMID: 17902732</identifier><language>eng</language><publisher>Auckland: Adis International</publisher><subject>Adult ; Age of Onset ; Aged ; Arthritis, Psoriatic - immunology ; Biological and medical sciences ; Case-Control Studies ; Dermatology ; Enzyme-Linked Immunosorbent Assay ; Epidemiology ; Female ; General aspects ; Gliadin - immunology ; Humans ; Immunoglobulin A - blood ; Immunoglobulin G - blood ; Male ; Medical sciences ; Middle Aged ; Prevalence ; Psoriasis - immunology ; Psoriasis. Parapsoriasis. Lichen ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Reference Values ; Severity of Illness Index</subject><ispartof>American journal of clinical dermatology, 2007-01, Vol.8 (5), p.301-305</ispartof><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 Wolters Kluwer Health, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-ad357f8761c454d30efdd4795f0f07f4e55085de6949147d0a41d57db5b0047f3</citedby><cites>FETCH-LOGICAL-c442t-ad357f8761c454d30efdd4795f0f07f4e55085de6949147d0a41d57db5b0047f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19178621$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17902732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIA, Kevin F</creatorcontrib><creatorcontrib>NAIR, Rajan P</creatorcontrib><creatorcontrib>IKE, Robert W</creatorcontrib><creatorcontrib>HIREMAGALORE, Ravi</creatorcontrib><creatorcontrib>ELDER, James T</creatorcontrib><creatorcontrib>ELLIS, Charles N</creatorcontrib><title>Prevalence of antigliadin antibodies in patients with psoriasis is not elevated compared with controls</title><title>American journal of clinical dermatology</title><addtitle>Am J Clin Dermatol</addtitle><description>Antigliadin antibodies (AGAs) are markers of celiac sprue but may have autoimmune implications in the absence of gastrointestinal disease. There is anecdotal evidence to suggest that gluten sensitivity may play a role in psoriasis, and patients with psoriasis in Europe have been reported to improve on a gluten-free diet.
To assess whether patients with psoriasis in the US have an increased prevalence of elevated AGAs.
A US sample of patients with psoriasis (n=100), patients with psoriasis and psoriatic arthritis (n=100), and age-matched control individuals without any personal or family history of autoimmune disorders (n=100) were tested for IgG and IgA AGAs.
No difference in the prevalence of abnormal AGAs among patients with psoriasis (14%), combined psoriasis and psoriatic arthritis (18%), and control individuals (19%) was observed. No significant correlations between AGA positivity and psoriasis severity, joint involvement, or age of onset of psoriasis or arthritis were observed.
We found no support for the results of prior studies showing that elevated AGAs occur with increased frequency in patients with psoriasis. Furthermore, the relatively high prevalence of abnormal AGAs in our control population suggests these antibodies may not be associated with autoimmune disease.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Arthritis, Psoriatic - immunology</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Dermatology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Gliadin - immunology</subject><subject>Humans</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin G - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Psoriasis - immunology</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Reference Values</subject><subject>Severity of Illness Index</subject><issn>1175-0561</issn><issn>1179-1888</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1rFDEUhoMotq7-BQmIejX1ZPI5l6WoFQr1Qq9DNh81MpOMSVbpvzfdXS2CNOcib5LnPYTzIoQJnI1E8HcAZFQgyTACSFDAYYC--CN0SoicBqKUerzXfAAuyAl6Vut3gLGXeIpOOgOjpOMpCp-L_2lmn6zHOWCTWryZo3Ex7fU2u-gr7qfVtOhTq_hXbN_wWnOJpsb-VHHKDfu5t2neYZuX1ZQu9pzNqZU81-foSTBz9S-O-wZ9_fD-y8XlcHX98dPF-dVgGRvbYBzlMigpiGWcOQo-OMfkxAMEkIF5zkFx58XEJsKkA8OI49Jt-RaAyUA36O2h71ryj52vTS-xWj_PJvm8q1oyLqiYJOnkmwdJoSglRIgOvjqAN31MOqaQWzH2DtbnZJroJHlnN-jsP1Qv55fYp-BD7Pf_GNTBYEuutfig1xIXU241AX0Xsv4Tsv4bst6H3K0vj1_fbRfv7o3HVDvw-giYas0cikk21ntuIlKJkdDfcJWuJw</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>KIA, Kevin F</creator><creator>NAIR, Rajan P</creator><creator>IKE, Robert W</creator><creator>HIREMAGALORE, Ravi</creator><creator>ELDER, James T</creator><creator>ELLIS, Charles N</creator><general>Adis International</general><general>Wolters Kluwer Health, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20070101</creationdate><title>Prevalence of antigliadin antibodies in patients with psoriasis is not elevated compared with controls</title><author>KIA, Kevin F ; NAIR, Rajan P ; IKE, Robert W ; HIREMAGALORE, Ravi ; ELDER, James T ; ELLIS, Charles N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-ad357f8761c454d30efdd4795f0f07f4e55085de6949147d0a41d57db5b0047f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Arthritis, Psoriatic - immunology</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Dermatology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Epidemiology</topic><topic>Female</topic><topic>General aspects</topic><topic>Gliadin - immunology</topic><topic>Humans</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin G - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Psoriasis - immunology</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Reference Values</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIA, Kevin F</creatorcontrib><creatorcontrib>NAIR, Rajan P</creatorcontrib><creatorcontrib>IKE, Robert W</creatorcontrib><creatorcontrib>HIREMAGALORE, Ravi</creatorcontrib><creatorcontrib>ELDER, James T</creatorcontrib><creatorcontrib>ELLIS, Charles N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>American journal of clinical dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIA, Kevin F</au><au>NAIR, Rajan P</au><au>IKE, Robert W</au><au>HIREMAGALORE, Ravi</au><au>ELDER, James T</au><au>ELLIS, Charles N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of antigliadin antibodies in patients with psoriasis is not elevated compared with controls</atitle><jtitle>American journal of clinical dermatology</jtitle><addtitle>Am J Clin Dermatol</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>8</volume><issue>5</issue><spage>301</spage><epage>305</epage><pages>301-305</pages><issn>1175-0561</issn><eissn>1179-1888</eissn><abstract>Antigliadin antibodies (AGAs) are markers of celiac sprue but may have autoimmune implications in the absence of gastrointestinal disease. There is anecdotal evidence to suggest that gluten sensitivity may play a role in psoriasis, and patients with psoriasis in Europe have been reported to improve on a gluten-free diet.
To assess whether patients with psoriasis in the US have an increased prevalence of elevated AGAs.
A US sample of patients with psoriasis (n=100), patients with psoriasis and psoriatic arthritis (n=100), and age-matched control individuals without any personal or family history of autoimmune disorders (n=100) were tested for IgG and IgA AGAs.
No difference in the prevalence of abnormal AGAs among patients with psoriasis (14%), combined psoriasis and psoriatic arthritis (18%), and control individuals (19%) was observed. No significant correlations between AGA positivity and psoriasis severity, joint involvement, or age of onset of psoriasis or arthritis were observed.
We found no support for the results of prior studies showing that elevated AGAs occur with increased frequency in patients with psoriasis. Furthermore, the relatively high prevalence of abnormal AGAs in our control population suggests these antibodies may not be associated with autoimmune disease.</abstract><cop>Auckland</cop><pub>Adis International</pub><pmid>17902732</pmid><doi>10.2165/00128071-200708050-00005</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Age of Onset Aged Arthritis, Psoriatic - immunology Biological and medical sciences Case-Control Studies Dermatology Enzyme-Linked Immunosorbent Assay Epidemiology Female General aspects Gliadin - immunology Humans Immunoglobulin A - blood Immunoglobulin G - blood Male Medical sciences Middle Aged Prevalence Psoriasis - immunology Psoriasis. Parapsoriasis. Lichen Public health. Hygiene Public health. Hygiene-occupational medicine Reference Values Severity of Illness Index |
| title | Prevalence of antigliadin antibodies in patients with psoriasis is not elevated compared with controls |
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