Design, synthesis and biological evaluation of estradiol–chlorambucil hybrids as anticancer agents

The synthesis of a series of estradiol–chlorambucil hybrids is reported. The hybrids showed significant in vitro anticancer activity when compared to chlorambucil on breast cancer cell lines. A series of estradiol–chlorambucil hybrids was synthesized as anticancer drugs for site-directed chemotherap...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-03, Vol.20 (5), p.1614-1618
Hauptverfasser:	Gupta, Atul, Saha, Pijus, Descôteaux, Caroline, Leblanc, Valérie, Asselin, Éric, Bérubé, Gervais
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer agents Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Biological and medical sciences Breast cancer Cell Line, Tumor Chlorambucil - chemical synthesis Chlorambucil - chemistry Chlorambucil - toxicity Drug Design Estradiol - chemical synthesis Estradiol - chemistry Estradiol - toxicity Estradiol–chlorambucil hybrids Estrogen receptor General aspects Humans Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship
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