Synthesis and anti-microbial activity of some new fluorinated 1H-pyrazoles
Several new trifluoromethyl-1H-pyrazoles were prepared by reaction of hydrazine monohydrate with 1,3-diketones. Their structures were confirmed by elemental analysis, IR, super(1)H NMR and EI-MS spectroscopy. The anti-microbial activities of the newly synthesized compounds were examined by disc diff...
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Veröffentlicht in: | Journal of fluorine chemistry 2010-05, Vol.131 (5), p.584-586 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Several new trifluoromethyl-1H-pyrazoles were prepared by reaction of hydrazine monohydrate with 1,3-diketones. Their structures were confirmed by elemental analysis, IR, super(1)H NMR and EI-MS spectroscopy. The anti-microbial activities of the newly synthesized compounds were examined by disc diffusion method against Escherichia coli, Staphylococcus aureus, Pyricularia oryzae and Rhizoctnia solani. All the trifluoromethyl-1H-pyrazoles exhibited a certain degree of anti-bacterial and anti-fungal activities. |
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ISSN: | 0022-1139 |
DOI: | 10.1016/j.jfluchem.2010.01.005 |