Synthesis and anti-microbial activity of some new fluorinated 1H-pyrazoles

Several new trifluoromethyl-1H-pyrazoles were prepared by reaction of hydrazine monohydrate with 1,3-diketones. Their structures were confirmed by elemental analysis, IR, super(1)H NMR and EI-MS spectroscopy. The anti-microbial activities of the newly synthesized compounds were examined by disc diff...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of fluorine chemistry 2010-05, Vol.131 (5), p.584-586
Hauptverfasser: Wang, Dun-Jia, Fan, Ling, Zheng, Chun-Yang, Fang, Zheng-Dong
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Several new trifluoromethyl-1H-pyrazoles were prepared by reaction of hydrazine monohydrate with 1,3-diketones. Their structures were confirmed by elemental analysis, IR, super(1)H NMR and EI-MS spectroscopy. The anti-microbial activities of the newly synthesized compounds were examined by disc diffusion method against Escherichia coli, Staphylococcus aureus, Pyricularia oryzae and Rhizoctnia solani. All the trifluoromethyl-1H-pyrazoles exhibited a certain degree of anti-bacterial and anti-fungal activities.
ISSN:0022-1139
DOI:10.1016/j.jfluchem.2010.01.005