Comprehensive mapping of immunodominant and conserved serotype- and group-specific B-cell epitopes of nonstructural protein 1 from dengue virus type 1

Abstract The dengue virus (DENV) nonstructural protein 1 (NS1) is an immunogenic protein that holds potential for the development of vaccines and diagnostic reagents; however, the epitopes of NS1 have not been comprehensively mapped. We mapped B-cell linear epitopes on NS1 using 149 monoclonal antib...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2010-03, Vol.398 (2), p.290-298
Hauptverfasser:	Chen, Yue, Pan, Yuxian, Guo, Yonghui, Qiu, Liwen, Ding, Xixia, Che, Xiaoyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology B-lymphocytes Blotting, Western Cell Line Chromosome Mapping Conserved Sequence - genetics cross reaction Cross Reactions - genetics Cross Reactions - immunology Dengue virus Dengue Virus - classification Dengue Virus - genetics Dengue Virus - immunology Dengue virus type 1 Epitopes Epitopes, B-Lymphocyte - genetics Epitopes, B-Lymphocyte - immunology humoral immunity Immunodominant Epitopes - genetics Immunodominant Epitopes - immunology Infectious Disease Mice monoclonal antibodies Nonstructural protein 1 Sequence Alignment serotypes Serotyping viral antigens viral nonstructural proteins viral proteins Viral Proteins - genetics Viral Proteins - immunology
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