Effective ex vivo expansion of hematopoietic stem cells using osteoblast-differentiated mesenchymal stem cells is CXCL12 dependent

Effective ex vivo expansion of hematopoietic stem cells (HSCs) is a prerequisite for HSC transplantation. Growth and maintenance of HSC is dependent on cytokine and niche factors. We investigated whether mesenchymal stem cells (MSCs) or osteogenic cytokine‐differentiated MSCs play a role in HSC expa...

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Veröffentlicht in:	European journal of haematology 2010-06, Vol.84 (6), p.538-546
Hauptverfasser:	Mishima, Seiji, Nagai, Atsushi, Abdullah, Sk, Matsuda, Chikashi, Taketani, Takeshi, Kumakura, Shunichi, Shibata, Hiroshi, Ishikura, Hiroto, Kim, Seung U., Masuda, Junichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipocytes - metabolism Cell Differentiation Cell Line Chemokine CXCL12 - antagonists & inhibitors Chemokine CXCL12 - genetics Chemokine CXCL12 - metabolism Coculture Techniques Colony-Forming Units Assay CXCL12 ex vivo expansion Fetal Blood - cytology Fetal Blood - metabolism Hematopoiesis hematopoietic stem cell Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans mesenchymal stem cell Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Multipotent Stem Cells - cytology Multipotent Stem Cells - metabolism osteoblast Osteoblasts - cytology Osteoblasts - metabolism Platelet Factor 4 - metabolism RNA, Small Interfering - genetics Signal Transduction
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