Combined 677CC/1298AC genotypes of methylenetetrahydrofolate reductase (MTHFR ) reduce susceptibility to precursor B lymphoblastic leukemia in a Chinese population

The methylenetetrahydrofolate reductase (MTHFR) encodes a major enzyme in folate metabolism. It has been suggested that two MTHFR polymorphisms, 677C>T and 1298A>C, influence risk of acute lymphoblastic leukemia (ALL). Most studies on relation of MTHFR polymorphisms to ALL susceptibility have...

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Veröffentlicht in:	European journal of haematology 2010-06, Vol.84 (6), p.506-512
Hauptverfasser:	Lv, Ling, Wu, Cuie, Sun, Henjuan, Zhu, Saijuan, Yang, Yongchen, Chen, Xi, Fu, Hua, Bao, Liming
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Adult Aged Asian Continental Ancestry Group - genetics Base Sequence Case-Control Studies China Confidence Intervals DNA Primers - genetics Female Gender Gene Frequency Genetic Predisposition to Disease Genotype Haplotypes Humans Male Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged MTHFR Odds Ratio Polymorphism Polymorphism, Single Nucleotide Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - enzymology Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Sex Characteristics Susceptibility
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