Role of the 207–218 peptide region of Moloney murine leukemia virus integrase in enzyme catalysis

X-ray diffraction data on a few retroviral integrases show a flexible loop near the active site. By sequence alignment, the peptide region 207–218 of Mo-MLV IN appears to correspond to this flexible loop. In this study, residues H208, Y211, R212, Q214, S215 and S216 of Mo-MLV IN were mutated to dete...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2010-03, Vol.495 (1), p.28-34
Hauptverfasser:	Acevedo, Mónica L., Arbildúa, José Jaime, Monasterio, Octavio, Toledo, Héctor, León, Oscar
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence B-factor Catalysis Flexible loop Integrase Integrases - chemistry Integrases - genetics Integrases - metabolism Models, Molecular Molecular modeling Moloney murine leukemia virus Moloney murine leukemia virus - enzymology Moloney murine leukemia virus - genetics Mutagenesis Mutagenesis, Site-Directed Mutation Protein Structure, Tertiary Retrovirus Sequence Alignment Virus Integration
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