Advantages of the high resolution melting in the detection of BRCA1 or BRCA2 mutation carriers

The aim of the study is to explore the reliability of the high resolution melting (HRM) analysis for the identification of BRCA1/ BRCA2 mutation carriers among the family members of index patient (IP) and for distinguishing the presence of two or more genetic variants within the same amplicon. We st...

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Veröffentlicht in:	Clinical biochemistry 2009-10, Vol.42 (15), p.1572-1576
Hauptverfasser:	Jiménez, Inmaculada de Juan, Cardeñosa, Eva Esteban, Suela, Sarai Palanca, González, Eva Barragán, Gilabert, Pascual Bolufer
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA1 BRCA2 Breast cancer DNA Mutational Analysis - economics DNA Mutational Analysis - instrumentation DNA Mutational Analysis - methods Familiar study Genes, BRCA1 Genes, BRCA2 Genetic Predisposition to Disease Genetic Testing - economics Genetic Testing - methods Genetic Variation Genetic variations Genotype Heterozygote High resolution melting analysis (HRM) Humans Mutation Mutations Nucleic Acid Denaturation
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