Preclinical Evaluation of a Recombinant Anti-Prostate Specific Membrane Antigen Single-Chain Immunotoxin Against Prostate Cancer

The prostate-specific membrane antigen (PSMA) is abundantly expressed on prostate cancer epithelial cells and its expression correlates with tumor progression. Therefore, a specific immunotherapy against this antigen may be a novel therapeutic option for the management of prostate cancer. We generat...

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Veröffentlicht in:	Journal of immunotherapy 2010-04, Vol.33 (3), p.262-271
Hauptverfasser:	WOLF, Philipp, ALT, Karen, WETTERAUER, David, BÜHLER, Patrick, GIERSCHNER, Dorothee, KATZENWADEL, Arndt, WETTERAUER, Ulrich, ELSÄSSER-BEILE, Ursula
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases - genetics ADP Ribose Transferases - immunology Animals Antigens, Surface - genetics Antigens, Surface - immunology Antineoplastic agents Bacterial Toxins - genetics Bacterial Toxins - immunology Biological and medical sciences Cell Line Cell Line, Tumor Cell Survival - drug effects Cell Survival - immunology Drug Screening Assays, Antitumor Exotoxins - genetics Exotoxins - immunology Glutamate Carboxypeptidase II - genetics Glutamate Carboxypeptidase II - immunology Gynecology. Andrology. Obstetrics Humans Immunotherapy Immunotoxins - genetics Immunotoxins - immunology Immunotoxins - pharmacology Male Male genital diseases Medical sciences Mice Mice, SCID Nephrology. Urinary tract diseases Pharmacology. Drug treatments Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Prostatic Neoplasms - prevention & control Pseudomonas Pseudomonas aeruginosa Exotoxin A Recombinant Proteins - immunology Single-Chain Antibodies - genetics Single-Chain Antibodies - immunology Tumor Burden - drug effects Tumors Tumors of the urinary system Urinary tract. Prostate gland Virulence Factors - genetics Virulence Factors - immunology Xenograft Model Antitumor Assays
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