Recent trends in non-viral vector-mediated gene delivery

Nucleic acids‐based next generation biopharmaceuticals (i.e., pDNA, oligonucleotides, short interfering RNA) are potential pioneering materials to cope with various incurable diseases. However, several biological barriers present a challenge for efficient gene delivery. On the other hand, developmen...

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Veröffentlicht in:Biotechnology journal 2009-11, Vol.4 (11), p.1559-1572
Hauptverfasser: Pathak, Atul, Patnaik, Soma, Gupta, Kailash Chand
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container_title Biotechnology journal
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creator Pathak, Atul
Patnaik, Soma
Gupta, Kailash Chand
description Nucleic acids‐based next generation biopharmaceuticals (i.e., pDNA, oligonucleotides, short interfering RNA) are potential pioneering materials to cope with various incurable diseases. However, several biological barriers present a challenge for efficient gene delivery. On the other hand, developments in nanotechnology now offer numerous non‐viral vectors that have been fabricated and found capable of transmitting the biopharmaceuticals into the cell and even into specific subcellular compartments like mitochondria. This overview illustrates cellular barriers and current status of non‐viral gene vectors, i.e., lipoplexes, liposomes, polyplexes, and nanoparticles, to relocate therapeutic DNA‐based nanomedicine into the target cell. Despite the awesome impact of physical methods (i.e., ultrasound, electroporation), chemical methods have been shown to accomplish high‐level and safe transgene expression. Further comprehension of barriers and the mechanism of cellular uptake will facilitate development of nucleic acids‐based nanotherapy for alleviation of various disorders.
doi_str_mv 10.1002/biot.200900161
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subjects Cationic polymers
Gene delivery
Gene Transfer Techniques
Genetic Vectors
Lipids
Lipopeptides
Liposomes
Nanomedicine - methods
Non-viral vectors
Pharmaceutical Vehicles
Polymers
RNA, Small Interfering
Transfection
title Recent trends in non-viral vector-mediated gene delivery
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